Immunostaining for Leu-7 in the diagnosis of thyroid carcinoma.
Immunostaining for Leu-7 in the diagnosis of thyroid carcinoma.
复制标题
Leu-7 免疫染色诊断甲状腺癌。
DOI：
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发表时间：
1994
影响因子：
4.6
通讯作者：
A. Diaz
中科院分区：
文献类型：
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作者：
T. Loy;G. Darkow;L. Spollen;A. Diaz
甲状腺良恶性病变的形态学区分可能是困难的。Leu-7抗原的免疫染色已被报道在甲状腺癌的诊断中是有用的。为了检测Leu-7免疫染色在甲状腺癌诊断中的特异性，我们使用HNK-1单克隆抗体和抗生物素蛋白-生物素复合物技术研究了66例甲状腺病变的福尔马林固定、石蜡包埋组织标本。Leu-7阳性反应见于33例良性甲状腺疾病中的11例（33%）和33例甲状腺癌中的27例（82%）。我们的结论是，免疫组化的Leu-7是没有特异性的甲状腺癌的诊断。
The morphologic distinction between benign and malignant thyroid lesions can be difficult. Immunostaining for the Leu-7 antigen has been reported to be useful in the diagnosis of thyroid carcinoma. To test the specificity of immunostaining for Leu-7 in the diagnosis of thyroid carcinoma, we studied formalin-fixed, paraffin-embedded tissue specimens obtained from 66 thyroid lesions using the HNK-1 monoclonal antibody to Leu-7 and an avidin-biotin-complex technique. Positive reactivity for Leu-7 was seen in 11 (33%) of 33 benign thyroid conditions and in 27 (82%) of 33 thyroid carcinomas. We conclude that immunostaining for Leu-7 is not specific in the diagnosis of thyroid carcinoma.