Assessment of distraction regenerate using quantitative bone scintigraphy
Assessment of distraction regenerate using quantitative bone scintigraphy
复制标题
DOI：
10.1097/01.sap.0000237634.38881.a1
复制
发表时间：
2007-03-01
影响因子：
1.5
通讯作者：
Yapici, Kerim
中科院分区：
文献类型：
--
作者：
Eski, Muhitdin;Ilgan, Seyfettin;Yapici, Kerim
在这项研究中，我们研究了定量骨闪烁扫描是否可用于评估牵引成骨（DO）后新骨的形成。对雄性 Sprague-Dawley 大鼠的右半下颌骨进行垂直截骨术，并应用定制的牵引装置。逐渐分散注意力后，将大鼠分为两个亚组，即第二周和第四周。在第二周和第四周拍摄头颅照片并进行闪烁扫描和组织形态测量分析。闪烁扫描结果显示与组织形态测量结果具有良好的相关性。将结果与假手术组（皮肤和肌肉切开并放置针，但不进行截骨术）和急性牵引（5 毫米急性牵引）组进行比较。与假手术组和急性分散组相比，逐渐分散组的闪烁扫描平均摄取率显着更高。定量骨闪烁扫描是评估 DO 和巩固的一种有前途的方法。可为骨再生的无创评价提供客观的定性和定量数据。
In this study, we examined whether quantitative bone scintigraphy can be used to assess new bone formation following distraction osteogenesis (DO). A vertical osteotomy was performed on the right hemimandible of male Sprague-Dawley rats, and a custom-made distraction device was applied. Following the gradual distraction, rats were divided into 2 subgroups, the second and fourth week. Cephalograms were taken and scintigraphic and histomorphometric analysis was performed at the second and fourth week. Scintigraphic findings showed good correlation with histomorphometric results. Results were compared with sham-operated (skin and muscle incision and placement of pin but no osteotomy) and acute distraction (5-mm acute distraction) groups. Scintigraphic mean uptake ratios were significantly higher in the gradual distraction group compared with the sham-operated and acute distraction groups. Quantitative bone scintigraphy is a promising method for the assessment of DO and consolidation. It could offer objective qualitative and quantitative data for the noninvasive evaluation of bony regenerate.