Drosophila FIT is a protein-specific satiety hormone essential for feeding control.
Drosophila FIT is a protein-specific satiety hormone essential for feeding control.
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果蝇 FIT 是一种蛋白质特异性饱腹感激素，对于控制摄食至关重要
DOI：
10.1038/ncomms14161
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发表时间：
2017-01-19
影响因子：
16.6
通讯作者：
Li Y
中科院分区：
文献类型：
--
作者：
Sun J;Liu C;Bai X;Li X;Li J;Zhang Z;Zhang Y;Guo J;Li Y
蛋白质稳态对动物的健康和寿命至关重要。然而，控制蛋白质喂养的机制仍然知之甚少。在果蝇中，蛋白质摄入诱导的摄食抑制（PIFI）是特异性的含蛋白质的食物，这种作用是由脂肪体（FB）肽介导的命名为女性特异性独立的Transformer（FIT）。当食用蛋白质食物时，FIT表达大大升高。果蝇血淋巴中分泌的FIT肽将这种代谢信息传递给大脑，从而促进果蝇胰岛素样肽2（DILP 2）的释放并抑制进一步的蛋白质摄入。有趣的是，Fit是一个性二态基因，因此蛋白质消耗诱导的胰岛素释放以及蛋白质喂养行为在两性之间也是二态的。因此，我们的研究结果揭示了一种蛋白质特异性饱腹激素，为摄食决定的复杂调节以及摄食行为中的性二态性提供了重要的见解。
Protein homeostasis is critical for health and lifespan of animals. However, the mechanisms for controlling protein feeding remain poorly understood. Here we report that in Drosophila, protein intake-induced feeding inhibition (PIFI) is specific to protein-containing food, and this effect is mediated by a fat body (FB) peptide named female-specific independent of transformer (FIT). Upon consumption of protein food, FIT expression is greatly elevated. Secreted FIT peptide in the fly haemolymph conveys this metabolic message to the brain, thereby promoting the release of Drosophila insulin-like peptide 2 (DILP2) and suppressing further protein intake. Interestingly, Fit is a sexually dimorphic gene, and consequently protein consumption-induced insulin release, as well as protein feeding behaviour, are also dimorphic between sexes. Thus, our findings reveal a protein-specific satiety hormone, providing important insights into the complex regulation of feeding decision, as well as the sexual dimorphism in feeding behaviour.