Regulatory T cells overexpress a subset of Th2 gene transcripts
Regulatory T cells overexpress a subset of Th2 gene transcripts
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DOI：
10.4049/jimmunol.168.3.1069
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发表时间：
2002-02-01
影响因子：
4.4
通讯作者：
Waldmann, H
中科院分区：
文献类型：
--
作者：
Zelenika, D;Adams, E;Waldmann, H
现在有令人信服的证据表明，CD4（+）T细胞亚群的作用是防止自身免疫和移植中的免疫病理学。我们克隆了针对男性移植抗原的CD4（+）T细胞，与Th1或Th2克隆不同，其抑制男性皮肤移植物的排斥反应，因此被认为是调节性T细胞的例子。我们已经确定，使用基因表达的系列分析，转录本，在调节性T细胞相比，Th1和Th2克隆过表达。这些转录物中的一些在耐受性皮肤移植物中而不是在排斥性皮肤移植物中增加，并且另外由幼稚小鼠的天然调节性CD4（+）CD25（+）亚群表达。这些基因包括前脑啡肽原、GM2神经节苷脂激活蛋白、糖皮质激素诱导的TNFR超家族成员18和整合素α（E）β（7）。它们似乎代表了与Th2细胞共享的转录物的子集，这表明移植耐受和正常的免疫调节可能代表了Th2样分化的独特形式。
There is now compelling evidence for subpopulations of CD4(+) T cells whose role is to prevent immune pathology in both autoimmunity and transplantation. We have cloned CD4(+) T cells against a male transplantation Ag that, unlike Th1 or Th2 clones, suppresses the rejection of male skin grafts and are therefore considered examples of regulatory T cells. We have identified, using serial analysis of gene expression, transcripts that are overexpressed in regulatory T cells compared with Th1 and Th2 clones. Some of these transcripts are increased in tolerated rather than rejecting skin grafts and in addition are expressed by the natural regulatory CD4(+)CD25(+) subpopulation of naive mice. These genes include prepro-enkephalin, GM2 ganglioside activator protein, glucocorticoid-induced TNFR superfamily member 18, and integrin alpha(E)beta(7). They seem to represent a subset of transcripts shared with Th2 cells, suggesting that transplantation tolerance and normal immunoregulation may represent a unique form of Th2-like differentiation.