Acute cortisol and behavior of dairy goat kids administered local anesthesia, topical anesthesia or systemic analgesia prior to cautery disbudding
Acute cortisol and behavior of dairy goat kids administered local anesthesia, topical anesthesia or systemic analgesia prior to cautery disbudding
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DOI：
10.1016/j.physbeh.2020.112942
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发表时间：
2020-08-01
影响因子：
2.9
通讯作者：
Plummer, Paul J.
中科院分区：
文献类型：
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作者：
Hempstead, Melissa N.;Lindquist, Taylor M.;Plummer, Paul J.
山羊幼崽的烧灼脱芽会导致热烧伤和组织破坏，从而导致急性和术后疼痛，并对动物福利产生负面影响。本研究的目的是评估与以下相关的急性皮质醇浓度和行为反应：（1）烧灼除芽前注射利多卡因环阻滞剂，并将其与盐水注射进行比较；（2）疼痛缓解策略（利多卡因环阻滞剂、局麻药局部低共熔混合物（EMLA）霜、口服美洛昔康）对烧灼除芽奶山羊的疼痛缓解策略。 60 只母鹿被分配到六种处理中的一种：(1) 不带疼痛缓解的驱芽 (DB)，(2) 驱芽前 20 分钟使用 1% 利多卡因 (DBLA) 环阻滞，(3) 驱芽前 20 分钟注射盐水 (DBSA)，(4) 驱芽前 60 分钟口服美洛昔康 (DBMEL)，(5) 驱芽前 60 分钟将 EMLA 霜擦入芽中(DBEM) 和 (6) 已处理但未驱除 (HAND)。在治疗前（-20和-5分钟）和治疗后（15和30分钟）采集血液样本，以评估血浆皮质醇浓度，并使用摄像机记录治疗期间的行为，以评估臀部运动、尾巴摇动和发声（值以数量/治疗表示）。 DBLA 和 DBSA 儿童在萌芽前 5 分钟（注射后）表现出皮质醇升高至基线以上（P = 0.01），这与萌芽后 15 分钟的皮质醇没有差异（P > 0.05）。 DBLA（5.5 +/- 0.8 和 6.9 +/- 1.2）和 DBSA 儿童（5.6 +/- 0.8 和 7.2 +/- 1.2）的臀部运动和尾巴晃动与 DB 儿童没有差异（P > 0.10）。 DBEM 儿童和 DBMEL 儿童在出芽后 30 分钟内皮质醇较基线升高（P < 0.05）。随着时间的推移，HAND 儿童的皮质醇水平没有变化 (P > 0.10)，并且与所有治疗组相比，臀部运动、摇尾和发声更少 (P
Cautery disbudding of goat kids causes thermal burns and tissue destruction, which results in acute and postoperative pain and negatively affects animal welfare. The objectives of this study were to evaluate acute cortisol concentrations and behavioral responses associated with (1) injecting a lidocaine ring block prior to cautery disbudding and comparing this to saline injections and (2) pain mitigation strategies (lidocaine ring block, topical eutectic mixture of local anesthetics (EMLA) cream, oral meloxicam) on cautery disbudded dairy goat kids. Sixty doe kids were allocated to one of six treatments: (1) disbudding without pain relief (DB), (2) a ring block using 1% lidocaine (DBLA) 20 min before disbudding, (3) saline injection (DBSA) 20 min before disbudding, (4) oral meloxicam 60 min before disbudding (DBMEL), (5) EMLA cream rubbed into the buds 60 min before disbudding (DBEM) and (6) handled but not disbudded (HAND). Blood was sampled pre- (-20 and -5 min) and post-treatment (15 and 30 min) to assess plasma cortisol concentrations and behavior during treatment was recorded using video cameras to assess rump movements, tail shakes and vocalizations (values presented as number/treatment). DBLA and DBSA kids showed elevated cortisol above baseline 5 min pre-disbudding (after injections) (P = 0.01), which was no different to cortisol 15 min post-disbudding (P > 0.05). Rump movements and tail shakes of DBLA (5.5 +/- 0.8 and 6.9 +/- 1.2) and DBSA kids (5.6 +/- 0.8 and 7.2 +/- 1.2) were no different to those of DB kids (P > 0.10). Cortisol was elevated from baseline for 30 min post-disbudding for DBEM kids and DBMEL kids (P 0.05). HAND kids showed no change in cortisol over time (P > 0.10) and performed fewer rump movements, tail shakes and vocalizations than all treatments (P