Detection of thymidylate synthase expression in lymph node metastases of colorectal cancer can improve the prognostic information.
Detection of thymidylate synthase expression in lymph node metastases of colorectal cancer can improve the prognostic information.
复制标题
检测结直肠癌淋巴结转移中胸苷酸合酶的表达可以改善预后信息。
DOI：
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发表时间：
2005
影响因子：
45.3
通讯作者：
H. Blomgren
中科院分区：
文献类型：
--
作者：
K. Ohrling;D. Edler;M. Hallström;P. Ragnhammar;H. Blomgren
目的
胸苷合成酶(TS)水平在原发性结直肠癌(CRC)中是一种预后指标。本研究的目的是确定TS在Dukes‘C-CRC淋巴结转移中的表达是否为一种预后标志物。
患者和方法
应用免疫组织化学和单抗TS-106对348例Dukes‘C结直肠癌原发灶和淋巴结转移灶组织中TS的表达进行了回顾性研究。所有患者都参加了我们之前对862名结直肠癌患者的研究，这些患者包括在北欧试验中，随机将患者分为单独手术组或手术加辅助化疗组。
结果
在整个研究组中，淋巴结转移中TS的表达是总体生存率(OS；P=0.02)和无瘤生存率(DFS；P=0.04)的一个独特的预后标志。在转移的淋巴结中TS的低表达与较好的临床结果相关。在仅接受手术治疗的患者亚组中，TS在淋巴结转移灶中的表达对OS(P=0.04)和DFS(P=0.03)也有预后价值，但对于接受以氟尿嘧啶为基础的辅助化疗的另一亚组(OS，P=0.5；DFS，P=.2)则不是这样。TS在原发肿瘤中的表达仅在仅接受手术治疗的患者中具有显著的预后价值(OS，P=.03；DFS，P=.03)，而不是在整个患者群体中。
结论
这些数据表明，淋巴结转移中TS的表达是Dukes‘C CRC患者的一个预后标志物。
PURPOSE
The level of thymidylate synthase (TS) in primary colorectal cancer (CRC) has been reported as a prognostic marker. The purpose of this study was to determine whether TS expression in lymph node metastases of Dukes' C CRC is a prognostic marker.
PATIENTS AND METHODS
TS expression in the primary tumor and lymph node metastases from 348 patients with Dukes' C CRC was retrospectively assessed using immunohistochemistry and the monoclonal antibody TS 106. The patients had all been enrolled onto our previous study of 862 CRC patients who were included in Nordic trials that randomly assigned the patients to either surgery alone or surgery plus adjuvant chemotherapy.
RESULTS
TS expression in lymph node metastases was a distinct prognostic marker in the entire study group for overall survival (OS; P = .02) and disease-free survival (DFS; P = .04). A low TS expression in the lymph node metastases correlated with a better clinical outcome. In the subgroup of patients treated with surgery alone, the expression of TS in lymph node metastases also had a prognostic value for OS (P = .04) and DFS (P = .03), but this was not the case for the other subgroup who received adjuvant fluorouracil-based chemotherapy (OS, P = .5; DFS, P = .2). The expression of TS in the primary tumor only had a significant prognostic value among patients who were treated with surgery alone (OS, P = .03; DFS, P = .03) and not among the entire patient population.
CONCLUSION
These data show that TS expression in lymph node metastases is a prognostic marker for patients with Dukes' C CRC.
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影响因子：
11.2
作者：
P. Johnston;H. Lenz;C. Leichman;K. Danenberg;C. Allegra;P. Danenberg;L. Leichman
通讯作者：
P. Johnston;H. Lenz;C. Leichman;K. Danenberg;C. Allegra;P. Danenberg;L. Leichman
肝脏肿瘤中胸苷酸合酶的表达是可切除的转移性结直肠癌患者生存和进展的预测因子。
DOI：
10.1200/jco.2003.06.060
发表时间：
2003
期刊：
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
影响因子：
--
作者：
Gonen,Mithat;Hummer,Amanda;Zervoudakis,Alice;Sullivan,Deidre;Fong,Yuman;Banerjee,Debabrata;Klimstra,David;Cordon-Cardo,Carlos;Bertino,Joseph;Kemeny,Nancy
通讯作者：
Kemeny,Nancy
影响因子：
45.3
作者：
Allegra, CJ;Paik, S;Wieand, HS
通讯作者：
Wieand, HS
DOI：
--
发表时间：
1998-05
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
H. Lenz;K. Hayashi;D. Salonga;K. Danenberg;P. Danenberg;R. Metzger;D. Banerjee;J. Bertino;S. Groshen;L. Leichman;C. Leichman
通讯作者：
H. Lenz;K. Hayashi;D. Salonga;K. Danenberg;P. Danenberg;R. Metzger;D. Banerjee;J. Bertino;S. Groshen;L. Leichman;C. Leichman
影响因子：
45.3
作者：
Leichman, CG;Lenz, HJ;Danenberg, PV
通讯作者：
Danenberg, PV