Adiponectin is present in cord blood but is unrelated to birth weight
Adiponectin is present in cord blood but is unrelated to birth weight
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DOI：
10.2337/diacare.26.8.2244
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发表时间：
2003-08-01
期刊：
影响因子：
16.2
通讯作者：
Johnstone, FD
中科院分区：
文献类型：
--
作者：
Lindsay, RS;Walker, JD;Johnstone, FD
目的：在成人中，脂联素降低与过度肥胖、2型糖尿病和高胰岛素血症有关。我们评估了脂联素是否存在于胎儿循环中，2)存在于孕妇糖尿病的胎儿循环中，以及3)与胎儿脐血胰岛素或肥胖有关。研究设计和方法-我们评估了大量糖尿病母亲(n=134)和对照母亲(n=45)的独生子女脐带血中的脂联素。结果-脂联素存在于脐带血中，并且在妊娠晚期出生的ODM中，脂联素的水平更高(Spearman r=0.18，P=0.03)。ODM组的脂联素水平略低于对照组(ODM 19.7+/-6.1比对照组21.8+/-5.3µg/ml；P=0.04)，尽管这种差异可能反映了两组不同的孕周(ODM 37.6+/-1.5周和对照组40.1+/-1.1周)。与成人相比，无论是对照组还是ODM，胎儿的脂联素水平与肥胖程度、血胰岛素或瘦素无关。结论-脂联素存在于脐带血中，但不像成人那样显示出与肥胖的预期生理关系。
OBJECTIVE - in adults, adiponectin is reduced in association with excess adiposity, type 2 diabetes, and hyperinsulinemia. We assessed whether adiponectin was 1) present in the-fetal circulation, 2) altered in the fetal circulation in the presence of maternal diabetes, and 3) had relations to fetal cord blood insulin or adiposity.RESEARCH DESIGN AND METHODS - We assessed adiponectin in cord blood in a large cohort of singleton offspring of diabetic mothers (ODM; n = 134) and control mothers (n = 45).RESULTS - Adiponectin was present in cord blood and, in ODM, was higher in those delivered at later gestational ages (Spearman r = 0.18, P = 0.03). Adiponectin was slightly lower in ODM than control subjects (ODM 19.7 +/- 6.1 vs. control 21.8 +/- 5.3 mug/ml; P = 0.04), although this difference could potentially reflect different gestational ages in the two groups (ODM 37.6 +/- 1.5 and control 40.1 +/- 1.1 weeks). In contrast to adults, adiponectin levels in the fetus were unrelated to the degree of adiposity, blood insulin, or leptin in either control subjects or ODM.CONCLUSIONS - Adiponectin is present in cord blood but does not show expected physiological relations with adiposity as observed in adults.