The growth inhibition of liver cancer cells by paclitaxel and the involvement of extracellular signal-regulated kinase and apoptosis.
The growth inhibition of liver cancer cells by paclitaxel and the involvement of extracellular signal-regulated kinase and apoptosis.
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紫杉醇对肝癌细胞生长的抑制以及细胞外信号调节激酶和细胞凋亡的参与。
DOI：
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发表时间：
2007
期刊：
影响因子：
--
通讯作者：
Y. Murawaki
中科院分区：
文献类型：
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作者：
J. Okano;T. Nagahara;Kazuya Matsumoto;Y. Murawaki
紫杉醇是一种用于治疗乳腺癌和非小细胞肺癌的化疗药物。然而，紫杉醇对肝细胞癌（HCC）的生物学作用尚不明确。我们用人肝癌细胞系检验了这些点，发现紫杉醇抑制肝癌细胞的生长，阻断G2/M期的细胞周期。由于caspase被弱激活，细胞凋亡介导了部分细胞死亡，泛caspase抑制剂部分挽救了细胞死亡。紫杉醇激活细胞外信号调节激酶（ERK），当ERK被丝裂原激活的ERK调节激酶抑制剂抑制时，紫杉醇诱导的细胞死亡和细胞周期阻滞得以恢复，表明紫杉醇通过ERK信号通路抑制细胞生长。我们的数据为紫杉醇在HCC患者治疗中的应用提供了前景。
Paclitaxel is a chemotherapeutic drug applied for the treatment of breast and non-small cell lung cancers. However, the biological effects of paclitaxel on hepatocellular carcinoma (HCC) are undefined. We examined these points by using the human HCC cell lines, and found that paclitaxel inhibited the growth of HCC cells and blocked the cell cycle at the G2/M phase. The cell death was partially mediated by apoptosis, because caspases were weakly activated and the cell death was partially rescued by a pan-caspase inhibitor. Paclitaxel activated extracellular signal-regulated kinase (ERK), and when ERK was inhibited by a mitogen-activated ERK-regulating kinase inhibitor, the cell death and cell cycle arrest induced by paclitaxel were rescued, demonstrating that paclitaxel inhibited the cellular growth via the ERK signaling pathway. Our data are promising for the application of paclitaxel in the treatment of patients with HCC.
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DOI：
10.1016/s0016-5085(08)83290-8
发表时间：
2001-04
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
J. Okano;Lorraine C. Snyder;A. Rustgi
通讯作者：
J. Okano;Lorraine C. Snyder;A. Rustgi
影响因子：
3.7
作者：
Seidman, R;Gitelman, I;Wolfson, M
通讯作者：
Wolfson, M
影响因子：
9.7
作者：
Gagandeep, S;Novikoff, PM;Gupta, S
通讯作者：
Gupta, S
影响因子：
10.6
作者：
Liu, Tsung-Yuan;Tsai, Wen-Hsiang
通讯作者：
Tsai, Wen-Hsiang