Endocytic trafficking of chemokine receptors.
Endocytic trafficking of chemokine receptors.
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DOI：
10.1016/j.ceb.2013.11.011
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发表时间：
2014-04
影响因子：
7.5
通讯作者：
Marchese, Adriano
中科院分区：
文献类型：
--
作者：
Marchese, Adriano
趋化因子受体属于G蛋白偶联受体（GPCR）超家族。趋化因子受体的同源配体是称为趋化因子的小循环蛋白质。在与其同源趋化因子结合后，受体迅速脱敏，内化到早期内体上，并分选到再循环途径或降解途径中。趋化因子受体运输是必不可少的，因为它通过从细胞表面去除受体从而限制接近其配体来限制信号传导的幅度和持续时间，但它也将结合的趋化因子递送至溶酶体进行降解。一旦在核内体上，受体被分选到有助于受体信号传导的再敏化的再循环途径中，或者它们被分选到导致信号传导的长期衰减的降解途径中。最近的研究揭示了一些关键信息的分子决定因素介导的趋化因子受体内化，并阐明了机制决定分类到回收或降解途径。在这里，我讨论了我们目前的理解的机制介导的趋化因子受体贩运的重点主要是最近的发现趋化因子受体CXCR4。
Chemokine receptors belong to the super family of G protein-coupled receptors (GPCRs). The cognate ligands for chemokine receptors are small circulating proteins known as chemokines. Upon binding to their cognate chemokines, receptors are rapidly desensitized, internalized onto early endosomes and sorted either into a recycling pathway or degradative pathway. Chemokine receptor trafficking is essential because it limits the magnitude and duration of signaling by removing receptors from the cell surface thereby limiting access to their ligands, but it also delivers bound chemokines to lysosomes for degradation. Once on endosomes receptors are sorted into a recycling pathway contributing to resensitization of receptor signaling or they are sorted into the degradative pathway leading to long-term attenuation of signaling. Recent studies have revealed some key information regarding the molecular determinants mediating chemokine receptor internalization and have shed light on the mechanisms dictating sorting into either the recycling or degradative pathways. Here I discuss our current understanding of the mechanisms mediating chemokine receptor trafficking with a focus primarily on recent findings for the chemokine receptor CXCR4.
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影响因子：
64.5
作者：
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影响因子：
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作者：
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DOI：
10.1083/jcb.201004060
发表时间：
2010-08-23
期刊：
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影响因子：
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作者：
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通讯作者：
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