High Salt Intake Attenuates Breast Cancer Metastasis to Lung
High Salt Intake Attenuates Breast Cancer Metastasis to Lung
复制标题
高盐摄入量可减轻乳腺癌肺转移
DOI：
10.1021/acs.jafc.7b05923
复制
发表时间：
2018
影响因子：
6.1
通讯作者：
Chen Wei
中科院分区：
文献类型：
--
作者：
Xu Yijuan;Wang Wenzhe;Wang Minmin;Liu Xuejiao;Lee Mee-Hyun;Wang Mingfu;Zhang Hao;Li Haitao;Chen Wei
Diet-related factors are thought to modify the risk of cancers, while the influence of high salt intake remains largely uncharacterized. Breast cancer is the most common cancer in women worldwide. In the present study, we examined the effect of salt intake on breast cancer by using a 4T1 mouse mammary tumor model. Unexpectedly, both the fitness and the survival rate of the tumor-bearing mice were improved by high salt intake. Similarly, high salt intake suppressed the primary tumor growth as well as metastasis to lung in mice. Mechanistically, high salt intake greatly reduced food intake and thus might exert antitumor effect through mimicking calorie restriction. Immunoblotting showed the lower proliferation marker Ki-67 and the higher expression of the tumor suppressor gene p53 in tumors of high salt intake mice. Importantly, high salt intake might induce hyperosmotic stress, which sensitized breast cancer cells to p53-dependent anoikis. Collectively, our findings raise the possibility that endogenous salt deposition might act as the first-line defense system against breast cancer progression as well as metastasis.
