A role for human skin-resident T cells in wound healing
A role for human skin-resident T cells in wound healing
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DOI：
10.1084/jem.20081787
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发表时间：
2009-04-13
影响因子：
15.3
通讯作者：
Havran, Wendy L.
中科院分区：
文献类型：
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作者：
Toulon, Antoine;Breton, Lionel;Havran, Wendy L.
表皮T细胞已被证明通过在皮肤中局部分泌不同的生长因子在小鼠的组织稳态和修复中发挥独特的作用。人类表皮含有α β（+）和γ δ（+）T细胞，其功能尚不清楚。我们证明，人表皮T细胞能够产生胰岛素样生长因子1（IGF-1）激活后，促进皮肤器官培养模型中的伤口愈合。此外，对从急性和慢性伤口分离的T细胞的功能能力的分析揭示了显著的差异。从急性伤口中分离的α β（+）和V δ 1（+）T细胞都能主动产生IGF-1，表明它们在组织损伤期间被激活以参与伤口修复。相反，在从慢性伤口分离的T细胞中不能检测到IGF-1的产生。事实上，从慢性伤口中分离的皮肤T细胞对进一步的刺激是难治的，表明无反应状态。总的来说，这些结果定义了人类表皮驻留T细胞在伤口愈合中的新作用，并为我们理解慢性伤口持续性提供了新的见解。
Epidermal T cells have been shown to play unique roles in tissue homeostasis and repair in mice through local secretion of distinct growth factors in the skin. Human epidermis contains both alpha beta(+) and gamma delta(+) T cells whose functional capabilities are not understood. We demonstrate that human epidermal T cells are able to produce insulin-like growth factor 1 (IGF-1) upon activation and promote wound healing in a skin organ culture model. Moreover, an analysis of the functional capabilities of T cells isolated from acute versus chronic wounds revealed a striking difference. Both alpha beta(+) and V delta 1(+) T cells isolated from acute wounds actively produced IGF-1, demonstrating that they are activated during tissue damage to participate in wound repair. In contrast, IGF-1 production could not be detected in T cells isolated from chronic wounds. In fact, skin T cells isolated from chronic wounds were refractory to further stimulation, suggesting an unresponsive state. Collectively, these results define a novel role for human epidermis-resident T cells in wound healing and provide new insight into our understanding of chronic wound persistence.