MiR-21: A key player in glioblastoma pathogenesis
MiR-21: A key player in glioblastoma pathogenesis
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DOI：
10.1002/jcb.26300
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发表时间：
2018-02-01
影响因子：
4
通讯作者：
Mirzaei, Hamed
中科院分区：
文献类型：
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作者：
Masoudi, Mohammad Sadegh;Mehrabian, Emadodin;Mirzaei, Hamed
多形性胶质母细胞瘤（GBM）是世界范围内发病率较高的常见肿瘤之一。尽管全世界都在努力，但GBM仍然是一种与预后不良相关的致命疾病。多系证据表明，多种细胞和分子通路的失调与GBM的发病有关。在参与GBM发病机制的多种靶点中，microRNAs （miRNAs）作为靶点已被发现，其失调与GBM的各个阶段有关。这些分子是小的非编码rna，可以影响GBM中涉及的各种细胞和分子途径。研究表明，它们的解除与GBM的发生和发展有关。MiR-21是参与GBM发病机制的重要mirna之一。大量研究表明，该miRNA可影响多种细胞和分子通路，如胰岛素样生长因子（IGF）结合蛋白-3 （IGFBP3）、RECK、TIMP3等。外泌体是GBM发病机制的重要参与者之一。在各种外泌体中，外泌体miR-21可能在GBM发病中起关键作用。这些发现表明miR-21在GBM发病机制中具有关键作用，可以作为GBM患者的诊断和治疗生物标志物。在这里，我们总结了miR-21和外泌体miR-21在GBM发病机制中的作用。此外，我们强调了miR-21作为GBM患者诊断和治疗生物标志物的应用。
Glioblastoma multiform (GBM) is one of common cancers worldwide which has high rate among various populations. Despite serious efforts worldwide, GBM remains a deadly disease which is associated with poor prognosis. Multiple lines evidence indicated that deregulation of a variety of cellular and molecular pathways are related with GBM pathogenesis. Among of various targets involved in GBM pathogenesis, microRNAs (miRNAs) have been emerged as targets which deregulation of them are related with various stages of GBM. These molecules are small non-coding RNAs which could affect on a variety of cellular and molecular pathways involved in GBM. It has been showed that deregulation of them are associated with initiation and progression of GBM. MiR-21 is one of important miRNAs involved in GBM pathogenesis. A large number studies indicated that this miRNA could affect on a variety of cellular and molecular pathways such as insulin-like growth factor (IGF)-binding protein-3 (IGFBP3), RECK, and TIMP3. Exosomes are one of important players in GBM pathogenesis. Among of various exosomes, exosomal miR-21 may has key roles in GBM pathogenesis. These findings indicated that miR-21 has critical roles in GBM pathogenesis and could be used as diagnostic and therapeutic biomarkers for GBM patients. Here, we summarized the roles of miR-21 and exosomal miR-21 in GBM pathogenesis. Moreover, we highlighted utilization of miR-21 as diagnostic and therapeutic biomarker for GBM patients.