Cholinergic modulation of separation distress in the domestic chick.
Cholinergic modulation of separation distress in the domestic chick.
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胆碱能调节家鸡的分离困扰。
DOI：
10.1016/0014-2999(81)90283-1
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发表时间：
1981
影响因子：
5
通讯作者：
A. Zolovick
中科院分区：
文献类型：
--
作者：
T. L. Sahley;J. Panksepp;A. Zolovick
本试验研究了尼古丁、氯巴酚、六甲溴铵和东莨菪碱对急性分离家雏鸡痛苦鸣叫的影响。尼古丁降低了分离诱导的DVs的频率，而抗毒东莨菪碱增加了分离诱导的DVs的频率。此外，东莨菪碱预处理可阻断尼古丁的应激减弱作用。这些结果暗示毒蕈碱受体参与控制分离诱导的痛苦，并支持尼古丁诱导的DV抑制可能是通过中枢释放乙酰胆碱激活与行为相关的毒蕈碱受体的结果。
The effects of nicotine, carbachol, hexamethonium and scopolamine were investigated on distress vocalizations (DVs) of acutely isolated domestic chicks. Nicotine atenuated, while the antimuscarinic scopolamine increased the frequency of separation-induced DVs. Furthermore, the stress attenuating effects of nicotine were blocked by pretreatment with scopolamine. These results implicate muscarinic receptor participation in the control of separation-induced distress, and support the suggestion that nicotine-induced DV suppression may result from activation of behaviorally relevant muscarinic receptors via central release of acetylcholine.