An extremely active catalyst for the Negishi cross-coupling reaction
An extremely active catalyst for the Negishi cross-coupling reaction
复制标题
DOI：
10.1021/ja0474493
复制
发表时间：
2004-10-13
影响因子：
15
通讯作者：
Buchwald, SL
中科院分区：
文献类型：
--
作者：
Milne, JE;Buchwald, SL
开发了一种新的钯催化有机锌试剂与卤代芳烃交叉偶联（Negishi偶联）的催化体系。该体系允许有效制备受阻联芳基（三-和四-邻位取代的），在低水平的催化剂下有效地起作用，并且耐受宽范围的官能团和杂环底物。对配体结构进行了系统的研究，并与催化剂活性进行了关联。
A new catalyst system for the Pd-catalyzed cross-coupling of organozinc reagents with aryl halides (Negishi coupling) has been developed. This system permits efficient preparation of hindered biaryls (tri-and tetra-ortho-substituted), functions effectively at low levels of catalyst, and tolerates a wide range of functional groups and heterocyclic substrates. A systematic study of ligand structure was performed and was correlated with catalyst activity.