The link between major risk factors and important categories of admission in an ageing cohort
The link between major risk factors and important categories of admission in an ageing cohort
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DOI：
10.1093/pubmed/22.1.81
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发表时间：
2000-03-01
期刊：
影响因子：
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通讯作者：
Gilhooly, MLM
中科院分区：
文献类型：
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作者：
Hanlon, P;Walsh, D;Gilhooly, MLM
背景：常规医院数据与基于人群的研究结果的记录联系为探索经典风险因素与医院活动之间的关系提供了机会。方法本研究的目的是在Paisley和Renfrew中检查危险因素变量对六种主要疾病急性住院可能性的影响。研究对象为8349名女性和7057名男性，年龄在45-64岁之间，时间在20世纪70年代早期到中期。主要观察指标为急性住院，主要诊断为：任何恶性肿瘤；气管、支气管、肺恶性肿瘤；缺血性心脏病；呼吸道疾病;脑血管疾病;或者糖尿病。结果吸烟者因肺癌入院的可能性几乎是吸烟者的8倍，除糖尿病外，吸烟者因其他疾病入院的可能性较小。用力呼气量也是肺癌和中风患者入院的独立危险因素。较高的胆固醇水平与缺血性心脏病的入院风险增加有关，但与癌症（包括肺癌）的入院风险较低。除脑血管疾病入院外，研究发现，剥夺类别对经历所检查的任何发病率结果的可能性没有独立影响。这些数据证实，首先在危险因素和死亡结果（如吸烟和肺癌）之间建立的关联，也在危险因素和因相同原因住院之间发现。这本身并不引人注目，但出于三个原因，其结果令人感兴趣。首先，它们说明了记录联系在绘制风险因素影响图方面的潜力。其次，它们证明了风险因素对入院风险的影响程度。第三，他们提供了一个令人惊讶的发现，即剥夺类别并不作为调查的大多数类别的入院的独立风险因素。
Background Record linkage of routine hospital data to population-based research findings presents an opportunity to explore the relationships between classical risk factors and hospital activity.Methods The objectives of this study were to examine, in Paisley and Renfrew, the effect of risk factor Variables on the likelihood of experiencing an acute hospital admission with six major medical conditions. The subjects were 8349 women and 7057 men, aged 45-64 in the early to mid-1970s. The main outcome measures were acute hospital admission with principal diagnosis of: any malignant neoplasm; malignant neoplasm of trachea, bronchus and lung; ischaemic heart disease; respiratory disease; cerebrovascular disease; or diabetes mellitus.Results Smokers were almost eight times more likely to be admitted with lung cancer and, to a lesser extent, were more likely to be admitted for the other conditions investigated with the exception of diabetes mellitus. Forced expiratory volume was also an independent risk factor for admission with lung cancer and strokes. Higher levels of cholesterol were associated with increased risk of admission with ischaemic heart disease but less with cancer (including lung cancer). With the exception of admissions for cerebrovascular disease, deprivation category was found to have no independent effect on the likelihood of experiencing any of the morbidity outcomes examined.Conclusions These data confirm that associations first established between risk factors and mortality outcomes (e.g. smoking and lung cancer) are also found between risk factors and hospital admissions for the same causes. This in itself is unremarkable, but the results are of interest for th ree reasons. First, they illustrate the potential of record linkage to map the effects of risk factors. Second, they demonstrate the size of the effect risk factors have on the risk of admission. Third, they provide a surprising finding that deprivation category does not act as an independent risk factor for the majority of the categories of admission investigated.