COMPARATIVE STUDIES OF THE INGESTIVE BEHAVIORS PRODUCED BY MICROINJECTIONS OF MUSCIMOL INTO THE MIDBRAIN RAPHE NUCLEI OR THE VENTRAL TEGMENTAL AREA OF THE RAT
COMPARATIVE STUDIES OF THE INGESTIVE BEHAVIORS PRODUCED BY MICROINJECTIONS OF MUSCIMOL INTO THE MIDBRAIN RAPHE NUCLEI OR THE VENTRAL TEGMENTAL AREA OF THE RAT
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DOI：
10.1016/0024-3205(88)90650-9
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发表时间：
1988-01-01
期刊：
影响因子：
6.1
通讯作者：
WIRTSHAFTER, D
中科院分区：
文献类型：
--
作者：
KLITENICK, MA;WIRTSHAFTER, D
在非剥夺大鼠的中缝正中核(MR)、中缝背核(DR)或腹侧被盖区(VTA)微量注射GABA-A激动剂蝇草酚，以剂量依赖和部位特异性的方式诱导强烈的摄食和饮水。与其他两个部位注射相比，MR注射增加食物摄入量、溢出量和水摄入量所需的蝇摩尔剂量更低。这些数据表明，MR是比DR或VTA更敏感的摄食行为诱发部位。
Microinjection of the GABA-A agonist muscimol into the median (MR) or dorsal (DR) raphe nuclei or the ventral tegmental area (VTA) of non-deprived rats induced intense feeding and drinking in a dose-dependent and site-specific manner. Lower doses of muscimol were required to increase food intake, spillage and water intake with injections into the MR than with injections into the other two sites. These data demonstrate that the MR is a more sensitive site for the elicitation of ingestive behavior than either the DR or the VTA.