The Snell dwarf mutation Pit1dw can increase life span in mice
The Snell dwarf mutation Pit1dw can increase life span in mice
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DOI：
10.1016/s0047-6374(01)00339-6
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发表时间：
2002-01-01
影响因子：
5.3
通讯作者：
Harrison, DE
中科院分区：
文献类型：
--
作者：
Flurkey, K;Papaconstantinou, J;Harrison, DE
在过去的30年里，据报道，斯内尔侏儒突变（Pit 1（dw））缩短。对不同的殖民地没有影响，或者增加它们的寿命：然而。这些不同的结果的一些细节已经公布，我们现在报告的意思。中位数最大寿命增加40- 50%，对于Snell侏儒（Pit 1（dw）/Pit 1（dw））DW/J雌性，和25- 50%，对于侏儒DWC 3F 1雄性和具有复合杂合Pit 1（dw）/Pit 1（dw/J）基因型的雌性。我们先前观察到斯内尔侏儒（Pit 1（dw）/Pit 1（dw/J））DW/J雄性的延迟衰老方面，然而，它们的中位寿命缩短了约25%（Genetic Effects on Aging 11，1990，The Telford Press考德威尔. NJ，pp. 435-456）。这种短暂的寿命不是突变的内在效应，而是将雄性侏儒与正常大小的雄性同窝仔一起居住的结果。我们目前的研究结果表明，斯内尔侏儒雄性与正常大小的雌性侏儒一起居住时，寿命很长。我们的结论是，侏儒突变与环境因素相互作用，改变寿命和。也许，衰老率的范围非常广泛。我们认为，这种变化的影响斯内尔侏儒突变的结果从身体活力和寿命之间的权衡，是由垂体激素介导的，生长激素，甲状腺激素，并可能催乳素调节机制，在哺乳动物中的时间表死亡率。(C)2002年由Elsevier Science爱尔兰有限公司出版。
Over the past 30 years, the Snell dwarf mutation (Pit1(dw)) has been reported to shorten. to have no effect on, or to increase life span in various colonies: however. few details of these disparate results have been published, We now report that mean. median. and maximum life spans are increased by 40-50%,, for Snell dwarf (Pit1(dw)/Pit1(dw)) DW/J females, and 25-50%, for dwarf DWC3F1 males and females with the compound heterozygous Pit1(dw)/Pit1(dw/J) genotype. We previously observed aspects of delayed senescence in Snell dwarf (Pit1(dw)/Pit1(dw/J)) DW/J males, however, their median life span was shortened by about 25% (Genetic Effects on Aging 11, 1990, The Telford Press Caldwell. NJ, pp. 435-456). This short life span was not an intrinsic effect of the mutation, but a consequence of housing male dwarfs with normal-sized male littermates our present results demonstrate that Snell dwarf males attain very long life spans when housed with normal-sized females. We conclude that the dwarf mutation interacts with environmental factors to alter life spans and. probably, rates of ageing, over an extremely broad range. We propose that this variation in the effect of the Snell dwarf mutation results from a tradeoff between physical vigor and life span that is mediated by pituitary hormones, and that growth hormone, thyroid hormone, and possibly prolactin regulate mechanisms that schedule mortality in mammals. (C) 2002 Published by Elsevier Science Ireland Ltd.