The Effects of Midline Cerebellar rTMS on Human Pharyngeal Cortical Activity in the Intact Swallowing Motor System.
The Effects of Midline Cerebellar rTMS on Human Pharyngeal Cortical Activity in the Intact Swallowing Motor System.
复制标题
中线小脑rTMS对完整吞咽运动系统人咽皮质活动的影响
DOI：
10.1007/s12311-020-01191-x
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发表时间：
2021-03
期刊：
影响因子：
--
通讯作者：
Hamdy S
中科院分区：
文献类型：
--
作者：
Sasegbon A;Niziolek N;Zhang M;Smith CJ;Bath PM;Rothwell J;Hamdy S
我们试图比较10 Hz小脑蚓部（与单侧半球和假手术）重复经颅磁刺激（rTMS）对皮层神经电活动的影响，以及此后10 Hz小脑蚓部（与假手术）rTMS对吞咽行为的影响。健康受试者（n = 25）被随机分配接受小脑蚓部，单侧半球或假10 Hz小脑rTMS。使用咽部肌电图和测压导管进行记录，获得运动诱发电位（MEP）和压力记录。在小脑刺激前和刺激后，测量了使用单脉冲TMS传递到双侧运动皮层咽部区域引起的MEP的幅度。如在先前的研究中，测量警察短展肌（APB）MEP以评估后rTMS调制特异性。使用吞咽准确性任务评估吞咽。在基线和干预后1小时的15分钟间隔进行测量。测量涉及TMS被用来引发10个MEP双边超过咽部地区的运动皮层，在APB皮质代表相邻的咽部地区与最低的静息运动阈值和5 MEP双边超过咽部地区的小脑半球。通过让参与者尝试吞咽10次并击中数字目标来评估吞咽准确性。与单侧rTMS和假手术组相比，小脑蚓部rTMS对皮层咽部MEP振幅产生显著抑制（P = 0.0005，0.002）。APB和小脑MEP振幅不受影响，咽部和APB MEP潜伏期也不受影响。与假手术组相比，小脑蚓部rTMS后吞咽准确性显著降低（P = 0.001）。我们的研究结果表明小脑蚓部rTMS对咽运动皮层活动和吞咽行为产生抑制作用。
We sought to compare the effects of 10 Hz cerebellar vermis (vs. unilateral hemispheric and sham) repetitive transcranial magnetic stimulation (rTMS) on cortical neuroelectrical activity and thereafter 10 Hz cerebellar vermis (vs. sham) rTMS on swallowing behaviour. Healthy participants (n = 25) were randomly allocated to receive vermis, unilateral hemisphere or sham 10 Hz cerebellar rTMS. Recordings were made using pharyngeal electromyography and manometry catheters, obtaining motor-evoked potentials (MEPs) and pressure recordings. The amplitudes of MEPs elicited using single-pulse TMS delivered to the pharyngeal areas of the motor cortex bilaterally were measured pre- and post-cerebellar stimulation. As in previous studies, abductor policis brevis (APB) MEPs were measured to assess post-rTMS modulation specificity. Swallowing was assessed using a swallowing accuracy task. Measurements were made at baseline and 15-min intervals for an hour post-intervention. Measurements involved TMS being used to elicit 10 MEPs bilaterally over the pharyngeal areas of the motor cortex, over the APB cortical representation adjacent to the pharyngeal area with the lowest resting motor threshold and 5 MEPs bilaterally over pharyngeal areas of the cerebellar hemispheres. Swallowing accuracy was assessed by giving participants 10 attempts to swallow and hit a digital target. Cerebellar vermis rTMS caused significant suppression of cortical pharyngeal MEP amplitudes compared with unilateral rTMS and sham (P = 0.0005, 0.002). APB and cerebellar MEP amplitudes were unaffected as were pharyngeal and APB MEP latencies. Following cerebellar vermis rTMS there was a significant reduction in swallowing accuracy compared with sham (P = 0.001). Our findings demonstrate cerebellar vermis rTMS exerts a suppressive effect on pharyngeal motor cortical activity and swallowing behaviour.
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影响因子：
10.6
作者：
Bohning, DE;Shastri, A;George, MS
通讯作者：
George, MS
DOI：
10.1016/j.jstrokecerebrovasdis.2009.01.009
发表时间：
2009-09-01
影响因子：
2.5
作者：
Falsetti, Paolo;Acciai, Caterina;Lenzi, Lucia
通讯作者：
Lenzi, Lucia
影响因子：
5.5
作者：
KERNELL, D;CHIENPIN.W
通讯作者：
CHIENPIN.W
影响因子：
5.5
作者：
BELL, FR;LAWN, AM
通讯作者：
LAWN, AM
影响因子：
29.4
作者：
Michou E;Mistry S;Jefferson S;Singh S;Rothwell J;Hamdy S
通讯作者：
Hamdy S