DNA REPLICATION AND RECOMBINATION AFTER UV IRRADIATION
DNA REPLICATION AND RECOMBINATION AFTER UV IRRADIATION
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DOI：
10.1101/sqb.1968.033.01.023
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发表时间：
1968-01-01
期刊：
影响因子：
--
通讯作者：
COLE, RS
中科院分区：
文献类型：
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作者：
HOWARDEL.P;RUPP, WD;COLE, RS
关于细菌和噬菌体DNA复制的最新研究已在本卷的许多论文中提出（Gellert等; Olivera等人; Ganesan; Okazaki et al.; Sadowski等人; Sinsheimer等人;和Huberman），这些提供了对本文主题的介绍--含有受损碱基的DNA的复制：当细胞暴露于辐射和诱变剂时，它们的DNA中会发生结构变化和受损碱基。许多受损的碱基可以被切除酶去除，这样DNA就可以在作为复制模板之前被修复。然而，其他受损的碱基可能会在DNA复制时保留在DNA中，并影响其作为DNA合成模板的性能。
Recent research on the replication of the DNA of bacteria and bacteriophages has been presented in a number of papers in this volume (Gellert et al.; Olivera et al.; Ganesan; Okazaki et al.; Sadowski et al.; Sinsheimer et al.; and Huberman), and these provide an introduction to the subject of this paper--the replication of DNA containing damaged bases:When cells are exposed to radiations and mutagenie agents, they suffer structural changes and damaged bases in their DNA. Many damaged bases may be removed by excision enzymes, so that the DNA can be repaired before it acts as template for replication. However, other damaged bases may remain in the DNA at the time it undergoes replication and affect its performance as template in DNA synthesis.