Intraocular pressure measurement in the conscious rat
Intraocular pressure measurement in the conscious rat
复制标题
在有意识的大鼠体内测量眼压
DOI：
10.1034/j.1600-0420.1999.770108.x
复制
发表时间：
1999-02-01
期刊：
影响因子：
--
通讯作者：
Cohan, BE
中科院分区：
文献类型：
--
作者：
Cabrera, CL;Wagner, LA;Cohan, BE
目的。建立清醒、非镇静状态下大鼠眼压的测量方法。用厚厚的布质手套轻轻抱住动物，滴入表面麻醉剂，然后将Tone-Pen涂抹在角膜上。在被研究的四个品系中，总共51只动物的测量结果没有显著差异：总体平均眼压+/-标准差为13.0+/-1.2毫米汞。从清醒大鼠的数据中计算出几个眼内压耐受极限，为未来的研究提供基线估计。这种在清醒大鼠身上的测量方法可能有助于使这种广泛使用的实验动物可用于眼压研究。
Purpose. To develop a method for measurement of intraocular pressure in conscious, unsedated rats.Methods. The animal was gently held with a thick fabric mitten, topical anesthetic drops were instilled and the Tone-Pen was applied to the cornea.Result. Measurements in a total of 51 animals did not differ significantly among four strains studied: the overall mean intraocular pressure+/-standard deviation was 13.0+/-1.2 mm Hg. Several intraocular pressure tolerance limits were calculated from this conscious rat data to provide a baseline estimate for future studies.Conclusions. This measurement method in conscious rats may contribute to making this widely used laboratory animal available for intraocular pressure research.