A CLINICAL-TRIAL OF IMMUNOSUPPRESSIVE THERAPY FOR MYOCARDITIS
A CLINICAL-TRIAL OF IMMUNOSUPPRESSIVE THERAPY FOR MYOCARDITIS
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DOI：
10.1056/nejm199508033330501
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发表时间：
1995-08-03
影响因子：
158.5
通讯作者：
ARTEAGA, W
中科院分区：
文献类型：
--
作者：
MASON, JW;OCONNELL, JB;ARTEAGA, W
背景。心肌炎是一种严重的疾病，治疗选择有限，本试验旨在确定免疫抑制治疗是否能改善心肌炎患者的左心室功能。我们随机分配111例组织病理学诊断为心肌炎且左心室射血分数小于0.45的患者，接受常规治疗或联合24周的免疫抑制治疗方案，免疫抑制治疗由强的松联合环孢素或硫唑嘌呤组成，主要结局指标是28周时左心室射血分数的变化。在整个组中，平均左室射血分数（+/-SE）从基线时的0.25+/-0.01改善到28周时的0.34+/-0.02 (P
Background. Myocarditis is a serious disorder, and treatment options are limited, This trial was designed to determine whether immunosuppressive therapy improves left ventricular function in patients with myocarditis.Methods. We randomly assigned 111 patients with a histopathological diagnosis of myocarditis and a left ventricular ejection fraction of less than 0.45 to receive conventional therapy alone or combined with a 24-week regimen of immunosuppressive therapy, Immunosuppressive therapy consisted of prednisone with either cyclosporine or azathioprine, The primary outcome measure was a change in the left ventricular ejection fraction at 28 weeks.Results. In the group as a whole, the mean (+/-SE) left ventricular ejection fraction improved from 0.25+/-0.01 at base line to 0.34+/-0.02 at 28 weeks (P