Dorsal striatal size, shape, and metabolic rate in never-medicated and previously medicated schizophrenics performing a verbal learning task
Dorsal striatal size, shape, and metabolic rate in never-medicated and previously medicated schizophrenics performing a verbal learning task
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DOI：
10.1001/archpsyc.55.3.235
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发表时间：
1998-03-01
影响因子：
--
通讯作者：
Luu-Hsia, C
中科院分区：
文献类型：
--
作者：
Shihabuddin, L;Buchsbaum, MS;Luu-Hsia, C
背景：采用磁共振成像和正电子发射断层扫描技术研究了18例精神分裂症（n=16）或精神分裂情感性障碍（n=2）患者和24例年龄和性别匹配的对照组的尾状核和壳核的大小和代谢率。方法：患者均为未用药（n=7）或无用药（n=11），中位数为3周。在摄取氟脱氧葡萄糖f18期间，所有患者都进行了一系列的语言学习测试。正电子发射断层扫描与磁共振成像扫描共配准，并在磁共振图像上追踪尾状核和壳核。结果：精神分裂症患者纹状体相对代谢率明显低于对照组。未服药的患者在右侧壳核（背纹状体腹侧）的代谢率低于先前服药的患者。未用药患者的尾状核明显小于对照组，而先前用药患者的尾状核最大。壳核相对代谢率较高的患者在异常不自主运动量表上得分较高。结论：研究结果与先前用药患者纹状体增大和抗精神病药物治疗后纹状体增大的报道一致。相比之下，从未服用过药物的患者的腹侧纹状体结构比对照组和先前服用过药物的患者更小，活性更低。
Background: Magnetic resonance imaging and positron emission tomography were used to study the size and metabolic rate of the caudate and the putamen in 18 patients with schizophrenia (n=16) or schizo-affective disorder (n=2) and 24 age-and sex-matched control subjects.Methods: The patients were either never medicated (n=7) or drug free (n=11) for a median of 3 weeks. During uptake of fludeoxyglucose F 18, all patients performed a serial verbal learning test. Positron emission tomographic and magnetic resonance imaging scans were coregistered, and the caudate and the putamen were traced on the magnetic resonance image.Results: The striatum had a significantly lower relative metabolic rate in schizophrenics than in controls. Never-medicated patients had lower metabolic rates in the right putamen (ventral part of the dorsal striatum) than previously medicated patients. The caudate was significantly smaller in never-medicated patients than in controls and largest in previously medicated patients. Patients with higher relative metabolic rates in the putamen scored higher on the Abnormal Involuntary Movements Scale.Conclusions: The findings are consistent with reports of striatal enlargement in previously medicated patients and size increases after neuroleptic treatment. Never-medicated patients, in contrast, had ventral striatal structures that were smaller and less active than those observed in controls and previously medicated patients.