Risk factors and prognostic impact of venous thromboembolism in Asian patients with non-small cell lung cancer
Risk factors and prognostic impact of venous thromboembolism in Asian patients with non-small cell lung cancer
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DOI：
10.1160/th13-11-0956
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发表时间：
2014-06-01
影响因子：
6.7
通讯作者：
Heo, Dae Seog
中科院分区：
文献类型：
--
作者：
Lee, Yun-Gyoo;Kim, Inho;Heo, Dae Seog
尽管非小细胞肺癌(NSCLC)患者发生静脉血栓栓塞症(VIE)的总体风险很高，但风险识别是有限的。这项研究的目的是评估亚洲非小细胞肺癌患者中VTE的发生率、危险因素和预后意义，并评估癌基因和VTE风险之间的遗传联系。共有1,998名连续的NSCLC患者入选并进行回顾性分析。由于治疗学对VIE发展的影响是分阶段修正的，因此进行了分层分析。当从VIE发展的角度比较总体生存时，采用倾向得分匹配的方法来最小化潜在的混淆。VTE的6个月和2年累积发生率分别为4.2%和6.4%。随着非小细胞肺癌的进展，VIE的风险增加了2.45倍(p
Although the overall risk of venous thromboembolism (VIE) is high in patients with non-small cell lung cancer (NSCLC), risk identification is limited. The goal of this study was to estimate the incidence, risk factors and prognostic implications of VTE, and to evaluate a genetic link between oncogenes and the risk of VTE in Asian patients with NSCLC.; A total of 1,998 consecutive patients with NSCLC were enrolled and analysed retrospectively. Since the effects of therapeutics on VIE development were modified by stage, stratified analyses were performed. When comparing overall survival in terms of VIE development, a propensity score-matching method was adopted to minimise potential confounding. The six-month and two-year cumulative incidences of VTE were 4.2% and 6.4%, respectively. The risk of VIE increased 2.45-fold with each advancing stage in NSCLC (p