Adiponectin: a relevant player in obesity-related colorectal cancer?
Adiponectin: a relevant player in obesity-related colorectal cancer?
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DOI：
10.1136/gutjnl-2012-303034
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发表时间：
2012-07
期刊：
影响因子：
24.5
通讯作者：
A. Cava
中科院分区：
文献类型：
--
作者：
A. Cava
肥胖是一种以身体脂肪质量异常增加为特征的疾病。在过去的几十年里，由于生活方式的改变，全球肥胖率急剧上升，导致整体体力活动减少，过量和/或高热量或加工食品的摄入量增加。因此，肥胖是当今一个主要的全球健康问题。特别是，几项流行病学研究已将肥胖与寿命缩短联系在一起，这主要是由于发生慢性疾病的风险较高，除胰岛素抵抗和2型糖尿病外，慢性疾病还包括心血管并发症，如高血压、冠心病和中风。1此外，肥胖还被证明增加了患不同类型肿瘤的风险，如食道癌、结肠癌、直肠癌、胰腺癌、胆囊癌、肾癌、乳腺癌、甲状腺癌和子宫内膜癌。2肥胖，低…
Obesity is a condition characterised by an abnormally elevated mass of body fat. The past decades have seen a dramatic rise in the worldwide incidence of obesity due to lifestyle changes that have led to an overall reduced physical activity and an increase in the intake of excessive and/or highly caloric or processed foods. As a consequence, obesity represents nowadays a major global health concern. In particular, several epidemiological studies have linked obesity to a shortened lifespan due primarily to a higher risk for the development of chronic pathologies that include cardiovascular complications such as high blood pressure, coronary heart disease and stroke, in addition to insulin resistance and type 2 diabetes.1 Additionally, obesity has also been shown to increase the risk of developing different types of tumours such as the cancer of the oesophagus, colon, rectum, pancreas, gallbladder, kidney, breast, thyroid and endometrium.2 In obesity, low …