Enhancement of transdermal drug delivery: chemical and physical approaches.
Enhancement of transdermal drug delivery: chemical and physical approaches.
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增强透皮药物递送：化学和物理方法。
DOI：
10.1615/critrevtherdrugcarriersyst.v17.i6.20
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发表时间：
2000
影响因子：
2.7
通讯作者：
B. Michniak
中科院分区：
文献类型：
--
作者：
C. Asbill;Ayman El;B. Michniak
在过去的二十年中，由于透皮给药途径提供的许多优点，透皮给药已被深入研究。然而，在透皮药物递送系统中使用的药物的数量受到一定的限制，这部分是由于皮肤的上层角质层对药物渗透具有强大的屏障。为了克服这一点，已经实施了不同的策略来使皮肤对药物更具渗透性。这些战略包括化学和物理方法。在这篇综述中，我们概述了一些研究更广泛的化学渗透促进剂（恶唑烷酮、丙二醇和表皮酶）的增强活性和作用机制。此外，我们还讨论了新的物理策略，如使用微针或电穿孔。
Transdermal drug delivery has been intensively studied over the last two decades because of the many advantages offered by this route of administration. However, the number of drugs used in transdermal drug delivery systems has been somewhat limited, in part resulting from the formidable barrier to drug permeation presented by the upper layer of the skin, the stratum corneum. In order to overcome this, different strategies have been implemented to render the skin more permeable to drugs. These strategies include both chemical and physical approaches. In this review, we outline the enhancing activities and mechanisms of action of some of the more extensively studied chemical penetration enhancers (oxazolidinones, propylene glycol, and epidermal enzymes). In addition, we discuss novel physical strategies, such as the use of microneedles or electroporation.