Immunological basis in the pathogenesis of intrahepatic cholestasis of pregnancy.
Immunological basis in the pathogenesis of intrahepatic cholestasis of pregnancy.
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DOI：
10.1586/1744666x.2016.1101344
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发表时间：
2016
影响因子：
4.4
通讯作者：
Agrawal DK
中科院分区：
文献类型：
--
作者：
Larson SP;Kovilam O;Agrawal DK
妊娠期肝内胆汁淤积对孕妇和胎儿的健康构成巨大风险。尽管进行了广泛的研究，但这种疾病的大部分发病机制尚不清楚。在妊娠期肝内胆汁淤积患者中观察到的胆汁酸增加会导致免疫系统从正常介导的 TH2 反应转变为更针对 TH1 的反应。在这篇文献综述中，我们批判性地回顾了有关免疫系统变化以及免疫学变化对患者管理的潜在影响的当前文献。还讨论了当前的治疗方法熊去氧胆酸以及潜在的联合疗法和未来的研究方向。
Intrahepatic cholestasis of pregnancy poses a great risk to both maternal and fetal health. Despite extensive research, much of the pathogenesis of this disorder is unknown. The increase in bile acids observed in patients with intrahepatic cholestasis of pregnancy has been noted to cause a change in the immune system from the normally mediated TH2 response to one that is more oriented towards TH1. In this literature review, we have critically reviewed the current literature regarding the changes in the immune system and the potential effects of immunological changes in the management of the patient. The current treatment, ursodeoxycholic acid, is also discussed along with potential combination therapies and future directions for research.