Skin-Homing Th2/Th22 Cells in Papuloerythroderma of Ofuji
Skin-Homing Th2/Th22 Cells in Papuloerythroderma of Ofuji
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DOI：
10.1159/000358588
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发表时间：
2014-01-01
期刊：
影响因子：
3.4
通讯作者：
Inoue, Yumiko
中科院分区：
文献类型：
--
作者：
Teraki, Yuichi;Inoue, Yumiko
Ofuji 丘疹红皮病 (PEO) 似乎是一种 T 细胞介导的皮肤病；然而，PEO的发病机制仍不清楚。我们报告了两例 PEO 病例，并检查了患者循环 T 细胞中细胞因子的产生和皮肤归巢受体的表达。 PEO 患者循环中产生白细胞介素 4 (IL-4)、IL-13 和 IL-22 的 CD4+ 和 CD8+T 细胞的百分比明显高于健康受试者。循环 CD4+ 和 CD8+ T 细胞中皮肤淋巴细胞抗原 (CLA) 和 CC 趋化因子受体 4 (CCR4) 的表达显着上调。此外，胸腺和活化调节趋化因子（TARC）（CCR4 的化学引诱剂）的血清水平也增加。 PEO完全缓解后，产生IL-4、IL-13和IL-22的T细胞数量、T细胞CLA和CCR4的表达以及血清TARC水平显着下降。这些结果表明皮肤归巢 Th2/Th22 细胞可能在 PEO 的发病机制中发挥作用。 (C) 2014 S. Karger AG，巴塞尔
Papuloerythroderma of Ofuji (PEO) appears to be a T cell-mediated skin disease; however, the pathogenesis of PEO remains unclear. We report two cases of PEO and examine cytokine production and expression of skin-homing receptors in circulating T cells in the patients. The percentages of interleukin 4 (IL-4)-, IL-13- and IL-22-producing CD4+ and CD8+T cells were markedly higher in the circulation of patients with PEO than in those of healthy subjects. The expression of both cutaneous lymphocyte antigen (CLA) and CC chemokine receptor 4 (CCR4) were significantly upregulated in the circulating CD4+ and CD8+ T cells. Moreover, serum levels of thymus and activation-regulated chemokine (TARC), a chemoattractant for CCR4, were increased. The number of IL-4-, IL-13- and IL-22-producing T cells, expression of CLA and CCR4 by T cells, and serum TARC levels significantly decreased after complete remission of PEO. These results suggest that skin-homing Th2/Th22 cells may play a role in the pathogenesis of PEO. (C) 2014 S. Karger AG, Basel