Severe Morbidity and Mortality Associated With Respiratory Syncytial Virus Versus Influenza Infection in Hospitalized Older Adults
Severe Morbidity and Mortality Associated With Respiratory Syncytial Virus Versus Influenza Infection in Hospitalized Older Adults
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DOI：
10.1093/cid/ciy991
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发表时间：
2019-07-15
影响因子：
11.8
通讯作者：
Shinde, Vivek
中科院分区：
文献类型：
--
作者：
Ackerson, Bradley;Tseng, Hung Fu;Shinde, Vivek
背景呼吸道合胞病毒（RSV）是老年人严重呼吸道疾病的重要原因。在住院老年人中比较RSV和流感感染可能会增加对成人RSV疾病负担的认识。从Kaiser Permanente Southern加州电子病历中确定了2011年1月1日至2015年6月30日期间RSV或流感检测呈阳性的≥ 60岁住院成人。比较两组患者的基线特征、合并症、使用情况和结局。该研究包括645名RSV感染和1878名流感感染住院成人。RSV患者比流感患者年龄大（平均78.5岁vs 77.4岁; P = 0.035），更可能发生充血性心力衰竭（35.3% vs 24.5%; P = 7天（比值比[OR] = 1.5; 95%置信区间[CI]，1.2-1.8; P = 0.001）。
Background. Respiratory syncytial virus (RSV) is an important cause of serious respiratory illness in older adults. Comparison of RSV and influenza infection in hospitalized older adults may increase awareness of adult RSV disease burden.Methods. Hospitalized adults aged >= 60 years who tested positive for RSV or influenza between 1 January 2011 and 30 June 2015 were identified from Kaiser Permanente Southern California electronic medical records. Baseline characteristics, comorbidities, utilization, and outcomes were compared.Results. The study included 645 RSV- and 1878 influenza-infected hospitalized adults. Patients with RSV were older than those with influenza (mean, 78.5 vs 77.4 years; P =.035) and more likely to have congestive heart failure (35.3% vs 24.5%; P = 7 days (odds ratio [OR] = 1.5; 95% confidence interval [CI], 1.2-1.8; P