Composition of Human Skin Microbiota Affects Attractiveness to Malaria Mosquitoes
Composition of Human Skin Microbiota Affects Attractiveness to Malaria Mosquitoes
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DOI：
10.1371/journal.pone.0028991
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发表时间：
2011-12-28
期刊：
影响因子：
3.7
通讯作者：
Smallegange, Renate C.
中科院分区：
文献类型：
--
作者：
Verhulst, Niels O.;Qiu, Yu Tong;Smallegange, Renate C.
严格意义上的非洲疟疾蚊子冈比亚按蚊继续在疟疾传播中发挥重要作用，由于其高度的寄生性，使其成为这一疾病的最主要病媒之一，疟疾的传播更加严重。在目前的研究中，我们着手解开这种蚊子物种与人类之间的强烈联系，因为它是由来自人类皮肤的气味线索决定的。皮肤上的微生物群落在人体气味的产生中起着关键作用。我们证明了皮肤微生物群的组成影响人类对这种蚊子物种的吸引力程度。细菌平板计数和16S rRNA测序显示，对An.冈比亚有限公司他们皮肤上的细菌数量明显高于那些不吸引人的人，但多样性却较低。鉴定了与蚊子的相对吸引程度相关的细菌属。皮肤微生物种群与蚊子吸引力之间的联系的发现可能会导致开发新的蚊子引诱剂和个性化的方法，以防止疟疾和其他传染病的媒介。
The African malaria mosquito Anopheles gambiae sensu stricto continues to play an important role in malaria transmission, which is aggravated by its high degree of anthropophily, making it among the foremost vectors of this disease. In the current study we set out to unravel the strong association between this mosquito species and human beings, as it is determined by odorant cues derived from the human skin. Microbial communities on the skin play key roles in the production of human body odour. We demonstrate that the composition of the skin microbiota affects the degree of attractiveness of human beings to this mosquito species. Bacterial plate counts and 16S rRNA sequencing revealed that individuals that are highly attractive to An. gambiae s.s. have a significantly higher abundance, but lower diversity of bacteria on their skin than individuals that are poorly attractive. Bacterial genera that are correlated with the relative degree of attractiveness to mosquitoes were identified. The discovery of the connection between skin microbial populations and attractiveness to mosquitoes may lead to the development of new mosquito attractants and personalized methods for protection against vectors of malaria and other infectious diseases.