Developmental origins of brain tumors.
Developmental origins of brain tumors.
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DOI：
10.1016/j.conb.2012.04.012
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发表时间：
2012-10
影响因子：
5.7
通讯作者：
Zong H
中科院分区：
文献类型：
--
作者：
Liu C;Zong H
Brain tumors are devastating due to the high fatality rate and the devastating impact on life qualities of patients. Recent advancement of comparative transcriptome profiling tools and mouse genetic models has greatly deepened our understanding of the developmental origins of these tumors, which could lead to effective therapeutic strategies. We review recent progresses in three types of brain tumors: ependymoma, medulloblastoma, and malignant glioma. The conceptual framework established by these studies converged on three important aspects. First, subtypes in each tumor group originate from distinct cell types. Second, each cell-of-origin is uniquely sensitive to some but not other genetic mutations. Lastly, mutant stem cells may not transform until they differentiate into more restricted progenitor cell type. Overall, these findings indicate the existence of intricate interactions between gene mutations and developmental context for the formation of brain tumors.
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影响因子：
50.3
作者：
Schueller, Ulrich;Heine, Vivi M.;Mao, Junhao;Kho, Alvin T.;Dillon, Allison K.;Han, Young-Goo;Huillard, Emmanuelle;Sun, Tao;Ligon, Azra H.;Qian, Ying;Ma, Qiufu;Alvarez-Buylla, Arturo;McMahon, Andrew P.;Rowitch, David H.;Ligon, Keith L.
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Ligon, Keith L.
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3.7
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Tasic B;Miyamichi K;Hippenmeyer S;Dani VS;Zeng H;Joo W;Zong H;Chen-Tsai Y;Luo L
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4.6
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AuBuchon, J. P.;de Wildt-Eggen, J.;Dumont, L. J.
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Dumont, L. J.
影响因子：
11.2
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Sharma, Mukesh K.;Mansur, David B.;Gutmann, David H.
通讯作者：
Gutmann, David H.
影响因子：
50.3
作者：
Bachoo, RM;Maher, EA;DePinho, RA
通讯作者：
DePinho, RA