GENE INTERACTION AT HLA-DQ ENHANCES AUTOANTIBODY PRODUCTION IN PRIMARY SJOGRENS-SYNDROME
GENE INTERACTION AT HLA-DQ ENHANCES AUTOANTIBODY PRODUCTION IN PRIMARY SJOGRENS-SYNDROME
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DOI：
10.1126/science.3458307
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发表时间：
1986-05-30
期刊：
影响因子：
56.9
通讯作者：
PROVOST, TT
中科院分区：
文献类型：
--
作者：
HARLEY, JB;REICHLIN, M;PROVOST, TT
原发性干燥综合征是一种自身免疫性疾病，其特征是口眼干燥。人类白细胞抗原（HLA）基因座DQ与结合RNA蛋白Ro/SSA和La/SSB的原发性干燥综合征自身抗体相关。DQ 1和DQ 2等位基因都与这些自身抗体的高浓度相关。对DQ所有可能组合的分析表明，整个效应是由于表达DQ 1和DQ 2等位基因的杂合子。这些数据表明，DQ 1和DQ 2（或相关位点的等位基因）之间的基因相互作用，可能来自反式相关表面分子的基因互补，影响原发性干燥综合征的自身免疫反应。
Primary Sjogren''s syndrome is an autoimmune disorder characterized by dryness of the mouth and eyes. The human leukocyte antigen (HLA) locus DQ is related to the primary Sjogren''s syndrome autoantibodies that bind the RNA proteins Ro/SSA and La/SSB. Both DQ1 and DQ2 alleles are associated with high concentrations of these autoantibodies. An analysis of all possible combinations at DQ has shown that the entire effect was due to heterozygotes expressing the DQ1 and DQ2 alleles. These data suggest that gene interaction between DQ1 and DQ2 (or alleles at associated loci), possibly from gene complementation of trans-associated surface molecules, influences the autoimmune response in primary Sjogren''s syndrome.