Steroid receptor expressions in endometrial cancer: Clinical significance and epidemiological implication
Steroid receptor expressions in endometrial cancer: Clinical significance and epidemiological implication
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DOI：
10.1016/j.canlet.2005.08.001
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发表时间：
2006-08-08
期刊：
影响因子：
9.7
通讯作者：
Song, Yong-Sang
中科院分区：
文献类型：
--
作者：
Jeon, Yong-Tark;Park, In-Ae;Song, Yong-Sang
评估雌激素受体(ER)和孕激素受体(PR)在子宫内膜癌中的表达水平是现代实践中非常常见的程序。然而，这种测试的意义仍然存在争议，评估类固醇受体的状态似乎是一种更彻底的正当做法。本研究对145名子宫内膜癌患者进行了研究，这些患者都在1993年至2002年期间在首尔国立大学医院接受过手术。石蜡包埋组织块切片，用抗ER和抗PR的单抗进行免疫组化染色。临床病理变量也进行了分析，ER和PR阳性的临界值为10%。进行多因素Cox回归分析，以评估几个临床病理和免疫组织化学协变量对患者生存的影响。ER阳性47例(32.4%)，PR阳性110例(75.9%)。PR阳性肿瘤患者比PR阴性肿瘤患者更年轻、更肥胖(P=0.020、0.016)。分化较好的肿瘤ER、PR阳性率较高(P=0.015，P<0.001)。ER和PR阳性肿瘤的肌层侵袭性显著低于对照组(P=0.042，0.002)。多因素Cox回归分析显示，ER和PR的表达与患者的生存期无明显相关性，仅FIGO分期是独立的预后因素。我们的结果表明，在手术前评估类固醇受体可能是有帮助的。低ER和高PR值提示，在子宫内膜癌病例中，类固醇受体的表达可能与种族差异和/或癌变过程中受体的顺序丢失有关。(C)2005爱思唯尔爱尔兰有限公司。保留所有权利。
The evaluation of expression levels of the estrogen receptor (ER) and progesterone receptor (PR) in endometrial cancer is a very common procedure in modem practice. However, the significance of such tests remains controversial, and the evaluation of the status of steroid receptors seems to be a more thoroughly justified practice. The present study was carried out with 145 endometrial cancer patients, all of whom had undergone operations at the Seoul National University Hospital, from 1993 to 2002. Paraffin-embedded tissue blocks were sectioned and immunostained with monoclonal anti-ER and anti-PR antibodies. Clinicopathological variables were also analyzed, with 10% cutoff values for ER and PR positivity. A multivariate Cox regression analysis was performed in order to estimate the influences of several clinicopathological and immunohistochemical covariates on patient survival. Forty seven specimens (32.4%) stained as ER positive, and 110 (75.9%) stained as PR-positive. Patients with PR-positive tumor tended to be both younger and more obese than patients with PR-negative tumors (P=0.020, 0.016). Well-differentiated tumors were found to be positive for ER or PR more frequently (P=0.015, < 0.001). ER or PR-positive tumors exhibited significantly less myometrial invasion (P=0.042, 0.002). However, multivariate Cox regression analyses revealed that the expressions of ER and PR were not significantly associated with patient survival, and only advanced FIGO stage constituted an independent prognostic factor. Our results suggested that the evaluation of steroid receptors might prove helpful prior to surgery. Low ER and high PR values suggest that racial differences and/or sequential loss of receptors during carcinogenesis might be involved in the expression of steroid receptors in cases of endometrial cancer. (c) 2005 Elsevier Ireland Ltd. All rights reserved.