Membrane potential changes in activated cells: Connection with cytosolic calcium oscillator
Membrane potential changes in activated cells: Connection with cytosolic calcium oscillator
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DOI：
10.1016/0303-2647(96)01619-x
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发表时间：
1996-01-01
期刊：
影响因子：
1.6
通讯作者：
Despa, SI
中科院分区：
文献类型：
--
作者：
Despa, SI
激素、生长因子或神经递质对许多细胞的激活可导致细胞膜电位的周期性变化。一个理论模型，描述这种行为的基础上的胞质钙振荡器的开发。该模型的主要假设强调质膜电位主要是K+扩散电位。结果表明，细胞内钙离子浓度的振荡可以单独引起膜电位振荡，而不存在离子通道间的相互作用机制。一个池模型被用来解释从细胞内存储的Ca2+释放。模型和数值计算是基于非线性动力系统理论。
The activation of many cells by hormones, growth factors or neurotransmitters can lead to a periodic variation of the cell membrane potential. A theoretical model that describes this behaviour on the basis of the cytosolic calcium oscillator is developed. The main assumption of this model stressed that the plasma membrane potential is mainly a K+ diffusion potential. Tt is shown that the oscillations of the intracellular calcium concentration can induce solely the membrane potential oscillations, without any further interaction mechanisms between fluxes through the ionic channels from the plasma membrane. A one-pool model was used to account for Ca2+ release from the intracellular stores. The model and the numerical calculations are based on the theory of nonlinear dynamical systems.