Biostability of micro-photodiode arrays for subretinal implantation
Biostability of micro-photodiode arrays for subretinal implantation
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DOI：
10.1016/s0142-9612(01)00185-5
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发表时间：
2002-02-01
期刊：
影响因子：
14
通讯作者：
Stelzle, M
中科院分区：
文献类型：
--
作者：
Hämmerle, H;Kobuch, K;Stelzle, M
基于半导体芯片技术的微型光电二极管阵列正在开发中，以取代视网膜中退化的感光细胞。电流在微小的微型光电二极管中产生，并通过微电极输送到邻近组织。视网膜下可植入装置的主要要求之一是相对于体内腐蚀的长期稳定性（生物稳定性）。研究了微光电二极管阵列（MPDA）的体内外生物稳定性。在盐水溶液中浸泡长达21个月的芯片上没有发现明显的损坏。在体内条件下。然而.芯片的氧化硅钝化层在约6-12个月的时间内溶解。随后。下面的硅被腐蚀。相比之下，由氮化钛组成的刺激电极在体外和体内均保存良好。微光电二极管的电性能的恶化与观察到的形态损伤相关。必须研究旨在开发神经技术植入物的改进的生物稳定封装的策略，并将简要讨论。(C)2001爱思唯尔科技有限公司版权所有。
Micro-photodiode arrays based on semiconductor Chip technology are being developed to replace degenerated photoreceptor cells in the retina. Electric Current is generated in tiny micro-photodiodes and delivered to the adjacent tissue by micro-electrodes. One of the main requirements of a sub-retinal implantable device is long-term stability versus corrosion in vivo (biostability). Biostability of micro-photodiode arrays (MPDA) was investigated in vitro and in vivo. No significant damage was found on chips immersed for up to 21 months in saline solution. Under in vivo conditions. however. the silicon oxide passivation layer of the chip was dissolved within a period of about 6-12 months. subsequently. the underlying silicon was corroded. In contrast, Stimulation electrodes consisting of titanium nitride were well preserved both in vitro and in vivo. The deterioration of the electrical properties of the micro-photodiodes correlated with the morphological damage observed. Strategies aiming at the development of an improved biostable encapsulation of neurotechnological implants have to be investigated and will be discussed briefly. (C) 2001 Elsevier Science Ltd. All rights reserved.