Diffusional kurtosis imaging: The quantification of non-Gaussian water diffusion by means of magnetic resonance imaging
Diffusional kurtosis imaging: The quantification of non-Gaussian water diffusion by means of magnetic resonance imaging
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DOI：
10.1002/mrm.20508
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发表时间：
2005-06-01
影响因子：
3.3
通讯作者：
Kaczynski, K
中科院分区：
文献类型：
--
作者：
Jensen, JH;Helpern, JA;Kaczynski, K
提出了一种定量水在生物组织中的非高斯扩散程度的磁共振成像方法。由于组织结构是导致水扩散偏离均匀溶液中典型观察到的高斯行为的原因，因此该方法提供了组织结构的特定测量，例如细胞室和膜。该方法是传统扩散加权成像的扩展，需要使用更高的b值和改进的图像后处理程序。除了扩散系数外，该方法还提供了扩散位移概率分布的过量峰度的估计，这是偏离高斯形式的无因次度量。通过对6名健康成人受试者的研究，发现白质的过度弥散峰度明显高于灰质，这反映了两种脑组织的结构差异。扩散峰度成像与q空间成像方法有关，但在成像时间、硬件要求和后处理工作量方面要求较低。它可用于评估与各种神经病变相关的组织结构异常。(c) 2005 Wiley-Liss, Inc。
A magnetic resonance imaging method is presented for quantifying the degree to which water diffusion in biologic tissues is non-Gaussian. Since tissue structure is responsible for the deviation of water diffusion from the Gaussian behavior typically observed in homogeneous solutions, this method provides a specific measure of tissue structure, such as cellular compartments and membranes. The method is an extension of conventional diffusion-weighted imaging that requires the use of somewhat higher b values and a modified image post-processing procedure. In addition to the diffusion coefficient, the method provides an estimate for the excess kurtosis of the diffusion displacement probability distribution, which is a dimensionless metric of the departure from a Gaussian form. From the study of six healthy adult subjects, the excess diffusional kurtosis is found to be significantly higher in white matter than in gray matter, reflecting the structural differences between these two types of cerebral tissues. Diffusional kurtosis imaging is related to q-space imaging methods, but is less demanding in terms of imaging time, hardware requirements, and postprocessing effort. It may be useful for assessing tissue structure abnormalities associated with a variety of neuropathologies. (c) 2005 Wiley-Liss, Inc.