Polylactic acid/sodium alginate/hydroxyapatite composite scaffolds with trabecular tissue morphology designed by a bone remodeling model using 3D printing
Polylactic acid/sodium alginate/hydroxyapatite composite scaffolds with trabecular tissue morphology designed by a bone remodeling model using 3D printing
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DOI：
10.1007/s10853-019-03537-1
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发表时间：
2019-07-01
影响因子：
4.5
通讯作者：
Maldonado-Garcia, A.
中科院分区：
文献类型：
--
作者：
Fernandez-Cervantes, I.;Morales, M. A.;Maldonado-Garcia, A.
本文提出了一种新的方法，采用3D打印技术生成聚乳酸，海藻酸钠和羟基磷灰石的微孔复合材料，其微观结构通过数学模型的3D数值解来设计。该模型反映了骨重建过程中成骨细胞和破骨细胞相互作用的时空动力学过程。复合材料的微孔结构模拟了人骨小梁的结构。该材料具有与天然骨组织所表现出的微孔非常接近的密度。材料的弹性模量与材料的加工工艺密切相关。当对该复合材料进行模拟体液处理时，由于羟基磷灰石晶体在其表面上的诱导矿化，对压缩的机械阻力增加。该方法显示出产生允许控制复合材料特性的结构的潜力。该材料具有微孔性，其形态学和化学性质适合于在组织工程中作为骨支架的未来应用。
The article presents a new methodology that employs 3D printing technology to generate a microporous composite material of polylactic acid, sodium alginate and hydroxyapatite, whose microstructure is designed by means of the 3D numerical solution from a mathematical model. This model represents the spatio-temporal dynamics of the interaction between osteoblasts and osteoclasts in the bone remodeling. The microporosity of composite material mimics the structure of human trabecular bone. This material has density with microporosity pretty close to the one that is exhibited by the natural bone tissue. Close relationship between the material processing and its elasticity module is observed. When subjecting this composite material to a simulated body fluid treatment, the mechanical resistance to compression is increased due to induced mineralization of hydroxyapatite crystals on its surface. The methodology shows potential to generate structures that allow the control of the composite material properties. The material presents a microporosity that has morphological and chemical properties suitable for future applications in tissue engineering as bone scaffold.