Advanced Technologies Lead iNto New Reprogramming Routes.

Advanced Technologies Lead iNto New Reprogramming Routes.
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先进技术引领新的重编程路线。

DOI:
10.1016/j.stem.2016.08.014
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发表时间:
2016
期刊:
影响因子:
23.9
通讯作者:
Qian,Li
Qian,Li
中科院分区:
医学1区
文献类型:
--
作者:
Zhou,Yang;Qian,Li

文献摘要

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最近的两篇论文提供了新的见解转录动力学和表观遗传重塑诱导神经元(iNs)的重编程过程中。Treutlein等人(2016)应用单细胞转录组学来识别早期iN诱导过程中的路线和弯路,而在本期Cell Stem Cell中,Black et al.(2016)采用基因编辑来激活重编程因子的内源性基因座。
Two recent papers provide new insights on transcriptional dynamics and epigenetic remodeling during reprogramming of induced neurons (iNs). Treutlein et al. (2016) applied single-cell transcriptomics to identify routes and detours during early iN induction, while in this issue ofCell Stem Cell, Black et al. (2016) employed gene editing to activate endogenous loci of the reprogramming factors.