EFFECT OF TREATMENT ON SOME PERIODONTOPATHOGENS AND THEIR ANTIBODY-LEVELS IN PERIODONTAL ABSCESSES
EFFECT OF TREATMENT ON SOME PERIODONTOPATHOGENS AND THEIR ANTIBODY-LEVELS IN PERIODONTAL ABSCESSES
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DOI：
10.1902/jop.1994.65.11.1022
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发表时间：
1994-11-01
影响因子：
4.3
通讯作者：
DAHLEN, GG
中科院分区：
文献类型：
--
作者：
HAFSTROM, CA;WIKSTROM, MB;DAHLEN, GG
对20例牙周脓肿患者进行了为期6个月的临床和微生物学随访。通过培养技术进行微生物检查。同时检查了同一患者的一个深牙周袋和一个浅牙周袋。收集血清并使用ELISA方法分析特异性抗体水平。治疗包括龈上刮治、引流和用0.85%氯化钠冲洗牙周袋，并全身给予四环素，每天1 g，持续2周。基线时，90%的患者携带牙龈卟啉单胞菌和/或中间普氏菌。6个月后，脓肿部位的探查深度减少，探查出血减少，附着增加。治疗后6个月，脓肿部位未显示牙龈卟啉单胞菌，中间卟啉单胞菌的比例显著降低。在深牙周袋中也观察到类似的模式。浅囊袋几乎没有炎症的临床体征，细菌数量通常较低。弯曲杆菌直，二氧化碳嗜纤维菌属，核梭杆菌在大多数网站在研究期间经常看到在低的数字，而放线共生放线杆菌只在少数网站检测到。患者血清中抗同源细菌菌株抗原的IgG水平在6个月内保持相当恒定。本研究结果提示牙龈卟啉单胞菌和中间卟啉单胞菌参与了牙周脓肿的形成。此外，引流与四环素给药相结合的治疗可促进愈合和再附着。
TWENTY PATIENTS SUFFERING FROM abscess of periodontal origin were treated and followed clinically and microbiologically for 6 months. Microbiological examination was performed by culture technique. One deep and one shallow periodontal pocket in the same patient were examined concomitantly. Serum was collected and analyzed for specific antibody level using ELISA methodology. Treatment included supragingival scaling, drainage, and irrigation of the periodontal pocket with 0.85% sodium chloride and systemic tetracycline administration, 1 g per day for 2 weeks. At baseline, 90% of the abscesses harbored Porphyromonas gingivalis and/or Prevotella intermedia. After 6 months, abscess sites demonstrated a reduced probing depth, less bleeding on probing, and gain of attachment. Abscess sites showed no P. gingivalis and the proportion of P. intermedia was significantly reduced 6 months after treatment. In deep periodontal pockets a similar pattern was seen. Shallow pockets demonstrated few clinical signs of inflammation and the number of bacteria was generally low. Campylobacter rectus, Capnocytophaga spp, and Fusobacterium nucleatum were frequently seen in low numbers in most sites during the study period, while Actinobacillus actinomycetemcomitans was detected only in a few sites. The IgG levels in patient sera against antigens of homologous bacterial strains remained fairly constant for 6 months. The result of the present study indicates that P. gingivalis and P. intermedia are involved in periodontal abscess formation. Also, treatment where drainage is combined with tetracycline administration promotes healing and reattachment.