Electrospun P(LLA-CL) nanofiber: a biomimetic extracellular matrix for smooth muscle cell and endothelial cell proliferation
Electrospun P(LLA-CL) nanofiber: a biomimetic extracellular matrix for smooth muscle cell and endothelial cell proliferation
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DOI：
10.1016/j.biomaterials.2003.08.042
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发表时间：
2004-05-01
期刊：
影响因子：
14
通讯作者：
Ramakrishna, S
中科院分区：
文献类型：
--
作者：
Mo, XM;Xu, CY;Ramakrishna, S
以l -丙交酯与epsilon-己内酯的比例为75比25的聚（l -丙交酯-co-epsilon-己内酯）[P(la - cl)]静电纺丝制成纳米纤维。研究了静电纺丝工艺参数与纤维直径的关系。纤维直径随聚合物浓度的降低和静电纺丝电压的升高而减小。x射线衍射仪和差示扫描比色仪结果表明，静电纺丝过程中纳米纤维在cl -单元序列上形成了高度定向的结构。通过在纳米纤维支架上培养细胞，研究了纳米纤维支架的生物相容性。平滑肌细胞和内皮细胞在P（la - cl）纳米纤维支架上粘附增殖良好。(C) 2003 Elsevier Ltd.版权所有。
Poly(L-lactide-co-epsilon-caprolactone) [P(LLA-CL)] with L-lactide to epsilon-caprolactone ratio of 75 to 25 has been electrospun into nanofibers. The relationship between electrospinning parameters and fiber diameter has been investigated. The fiber diameter decreased with decreasing polymer concentration and with increasing electrospinning voltage. The X-ray diffractometer and differential scanning colorimeter results suggested that the electrospun nanofibers developed highly oriented structure in CL-unit sequences during the electrospinning process. The biocompatibility of the nanofiber scaffold has been investigated by culturing cells on the nanofiber scaffold. Both smooth muscle cell and endothelial cell adhered and proliferated well on the P(LLA-CL) nanofiber scaffolds. (C) 2003 Elsevier Ltd. All rights reserved.