Experimental venous thrombi: MRI characteristics with histopathological correlation
Experimental venous thrombi: MRI characteristics with histopathological correlation
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DOI：
10.1259/bjr/37592039
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发表时间：
2012-04-01
影响因子：
2.6
通讯作者：
Miki, Y.
中科院分区：
文献类型：
--
作者：
Ichiki, M.;Sakai, Y.;Miki, Y.
目的：本研究的目的是评估猪模型静脉血栓在设定时间阈值内的MRI特征和组织病理学相关性。方法：对12头猪进行下腔静脉血栓诱导。3只猪在血栓诱导后2小时、1天、3天和2周进行MRI检查。结果：分析了MRI特征与组织病理学结果的相关性。2小时后的血栓由红细胞（rbc）组成，在T-1加权图像（T(1)WIs）上显示等强度，在T-2加权图像（T(2)WIs）和弥散加权图像（dwi）上显示高强度。平均表观扩散系数（ADC）为1.93 × 10(-3) mm(2) s（-1）。第1天后的血栓，由红细胞和周围迁移的中性粒细胞组成，在T(1) wi上呈等强度，在T(2) wi上呈轻微高强度，在dwi上呈低强度。平均ADC值为1.62 × 10(-3) mm/s（-2）。第3天的血栓由红细胞和包括巨噬细胞在内的外周炎症细胞组成，在T(1) wi上呈等强度的外周高强度区，在T(2) wi和dwi上均呈低强度区。平均ADC值为1.67 × 10(-3) mm(2) s（-1）。2周后，血栓显示被肉芽组织包围的红细胞溶解，在T(1) wi上显示等强度，在T(2) wi和dwi上显示高强度。平均ADC值为2.48 × 10(-3) mm(2) s（-1）。结论：颞叶MRI特征可能与红细胞和肉芽组织的化学和物理变化有关。巨噬细胞产生的自由基也可能与此有关。
Objectives: The purpose of this study was to evaluate the MRI characteristics of venous thrombus over set time thresholds with histopathological correlation in a porcine model.Methods: Inferior vena cava thrombi were induced in 12 pigs. MRI was performed in three pigs 2 h, 1 day, 3 days and 2 weeks after thrombus induction.Results: The MRI characteristics were analysed in correlation with histopathological findings. The thrombi after 2 hours, which consisted of red blood cells (RBCs), showed isointensity on T-1 weighted images (T(1)WIs) and hyperintensity on both T-2 weighted images (T(2)WIs) and diffusion-weighted images (DWIs). The mean apparent diffusion coefficient (ADC) value was 1.93 x 10(-3) mm(2) s(-1). The thrombi after Day 1, which consisted of RBCs and migrating neutrophils at the periphery, showed isointensity on T(1)WIs, slight hyperintensity on T(2)WIs and hypointensity on DWIs. The mean ADC value was 1.62 x 10(-3) mm/s(-2). The thrombi after Day 3, which consisted of RBCs and peripheral inflammatory cells including macrophages, showed isointensity with peripheral hyperintense regions on T(1)WIs and hypointensity on both T(2)WIs and DWIs. The mean ADC value was 1.67 x 10(-3) mm(2) s(-1). After 2 weeks, the thrombi, which revealed RBC lysis surrounded by granulation tissues, showed isointensity on T(1)WIs and hyperintensity on T(2)WIs and DWIs. The mean ADC value was 2.48 x 10(-3) mm(2) s(-1).Conclusion: The temporal MRI characteristics seemed to be related to chemical and physical changes in RBC and organisation of granulation tissues. Free radicals generated by macrophages might also be related to some extent.