Chronic exercise enhances insulin secretion ability of pancreatic islets without change in insulin content in non-diabetic rats.
Chronic exercise enhances insulin secretion ability of pancreatic islets without change in insulin content in non-diabetic rats.
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长期运动增强非糖尿病大鼠胰岛的胰岛素分泌能力而不改变胰岛素含量。
DOI：
10.1016/j.bbrc.2012.11.092
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Fujii NL.
中科院分区：
文献类型：
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作者：
Tsuchiya M;Manabe Y;Yamada K;Furuichi Y;Hosaka M;Fujii NL.
我们通过使用来自正常大鼠的分离胰岛的灌注方法评估了长期运动对高血糖反应下的胰岛素分泌的影响。雄性 Wistar 大鼠被分配到两组中的一组：久坐组和训练组。跑步锻炼每天在跑步机上进行一小时，每周五天，持续六周、九周或十二周。慢性运动在运动9周和12周后显着增强了胰岛响应高血糖刺激的胰岛素分泌能力。运动九周后，胰腺中的胰岛素含量和胰腺的重量没有变化。与久坐的大鼠相比，训练九周的大鼠的胰岛中钾刺激的胰岛素分泌也有所增加，这表明膜去极化下游的胰岛素分泌事件与运动效果的目标有关。这些发现表明，长期运动不仅对于维持外周胰岛素敏感性而且对于促进非糖尿病患者的胰岛功能分泌胰岛素来说可能是一种有用的策略。
We evaluated the effect of chronic exercise on insulin secretion in response to high-glucose by using a perifusion method with isolated pancreatic islets from normal rats. Male Wistar rats were assigned to one of two groups: a sedentary group and a trained group. Running exercise was carried out on a treadmill for one hour per day, five days per week, for six, nine, or 12 weeks. The chronic exercise significantly enhanced the insulin secretion ability of pancreatic islets in response to the high-glucose stimulation upon nine and 12 weeks of exercise. The insulin content in the pancreas and the weight of the pancreas did not change upon nine weeks of exercise. Potassium-stimulated insulin secretion was also increased in the islets isolated from rats that trained for nine weeks compared with that in sedentary rats, suggesting that insulin secretion events downstream of membrane depolarization are involved in targets of the exercise effect. These findings suggest that chronic exercise could be a useful strategy not only for the maintenance of peripheral insulin sensitivity but also for the promotion of islet function to secrete insulin in non-diabetics.