Correspondence between sharp tuning and two-tone inhibition in primary auditory neurones
Correspondence between sharp tuning and two-tone inhibition in primary auditory neurones
复制标题
初级听觉神经元的锐调和双音抑制之间的对应关系
作者：
D. Robertson
哺乳动物单个初级听觉神经元的频率选择性与基底膜的机械调谐差形成对比1，2。这种差异通常可以通过假设基底膜和听觉传入兴奋之间存在某种过滤机制来解释2 -4。这些神经元的另一个可能不能单独用基底膜行为解释的性质是双音抑制，即第二音的同时出现最好地降低了神经元对第一音的反应，或特征频率5 -8。有人提出，这种抑制也可能是基底膜9之后的额外耳蜗机制的一种特性。我现在提出的证据表明，主要神经元的急剧频率选择性的损失是密切相关的双音抑制的变化，这两种现象可能与一个共同的机制，这是容易受到外淋巴清除。
THE sharp frequency selectivity of single primary auditory neurones in mammals contrasts with the poor mechanical tuning of the basilar membrane1,2. This discrepancy has generally been explained by postulating some filter mechanism interposed between the basilar membrane and the excitation of auditory afferents2–4. A further property of these neurones which probably cannot be explained by basilar membrane behaviour alone is two-tone inhibition whereby the simultaneous presentation of a second tone reduces the response of a neurone to a first tone at the best, or characteristic frequency5–8. It has been suggested that this inhibition may also be a property of the additional cochlear mechanisms which follow the basilar membrane9. I now present evidence that the loss of sharp frequency selectivity of primary neurones is intimately linked to changes in two-tone inhibition and that the two phenomena might be related to a common mechanism which is vulnerable to perilymph removal.