Visual field damage in normal-tension glaucoma patients with or without ischemic changes in cerebral magnetic resonance imaging
Visual field damage in normal-tension glaucoma patients with or without ischemic changes in cerebral magnetic resonance imaging
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DOI：
10.1007/s10384-004-0072-0
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发表时间：
2004-07-01
影响因子：
2.4
通讯作者：
Masumoto, T
中科院分区：
文献类型：
--
作者：
Suzuki, J;Tomidokoro, A;Masumoto, T
目的：在单中心横断面研究中，利用脑磁共振成像（MRI）比较有缺血性改变征象的正常眼压青光眼（NTG）患者和无缺血性改变征象的NTG患者的视野损害模式。方法：对94例年龄小于61岁的NTG患者，采用液体衰减反转恢复脉冲序列获得脑MRI图像。脑MRI图像中缺血性变化迹象的存在是由两名神经放射科医生分别决定的，他们对青光眼的诊断和分期隐瞒。使用汉弗莱视野分析仪的30-2程序进行视野测试。脑MRI有缺血性改变征象的患者（缺血组）与无MRI征象的患者（非缺血组），比较各测点总偏差（total deviation， TD）减去30-2方案TDs的平均值（[TD - TDmean]）。结果：94例患者中有32例（34.0%）出现脑MRI缺血性改变征象。缺血组（N = 32）和非缺血组（N = 62）的年龄、血压、屈光、眼压、TDs平均值、平均偏差和校正模式标准差无显著性差异（P < 0.05）。下中心周至鼻野非边缘连续6个测试点，缺血组[TD -TDmean]显著小于非缺血组（P = 0.005 ~ 0.047）。结论：有脑MRI缺血性改变征象的NTG患者，其下中央周视野凹陷相对较深。(C)日本眼科学会2004。
Purpose: To compare the pattern of visual field damage between normal-tension glaucoma (NTG) patients with signs indicative of ischemic changes and those NTG patients without signs of ischemic changes, using brain magnetic resonance imaging (MRI), in a single center, cross-sectional study.Methods: In 94 consecutive NTG patients who were younger than 61 years old, brain MRI images were obtained using fluid-attenuated inversion recovery pulse sequences. The presence of signs indicative of ischemic changes in brain MRI images was decided separately by two neuroradiologists masked to the diagnosis and stage of glaucoma. Visual field testing was performed using the 30-2 program of the Humphrey Visual Field Analyzer. Between the patients with signs indicative of ischemic changes in brain MRI (ischemic group) and those without MRI signs (nonischemic group), total deviation (TD) at each test point less the average of TDs of the 30-2 program ([TD - TDmean])-was compared at each test point.Results: Signs indicative of ischemic changes in brain MRI were found in 32 of the 94 patients (34.0%). Age, blood pressure, refraction, intraocular pressure, the average of TDs, mean deviation, and corrected pattern standard deviation were not significantly different between the ischemic (N = 32) and nonischemic (N = 62) groups (P > 0.2). [TD -TDmean] in the ischemic group was significantly smaller than that in the nonischemic group at 6 nonedge contiguous test points in the inferior pericentral to nasal field (P = 0.005-0.047).Conclusion: NTG patients with signs indicative of ischemic changes in brain MRI had a relatively deeper depression in the inferior pericentral visual field. (C) Japanese Ophthalmological Society 2004.