Infectious complications of pancreatitis: diagnosis and management.
Infectious complications of pancreatitis: diagnosis and management.
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DOI：
10.1007/s11894-004-0079-1
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发表时间：
2004-08-01
影响因子：
--
通讯作者：
Pineau, Benoit C
中科院分区：
文献类型：
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作者：
Mishra, Girish;Pineau, Benoit C
感染性胰腺坏死是重症急性胰腺炎患者死亡的主要原因。早期预防性抗生素治疗可有效防止无菌坏死转化为胰腺感染，但其对死亡率的影响尚未得到证实。真菌感染可能预示着更糟糕的结果，但没有证据支持使用抗真菌预防。由于尽管采取预防措施，肠道细菌感染胰腺坏死仍可能发生，因此应高度怀疑，以便及早发现并积极治疗。
Infected pancreatic necrosis is the leading cause of death in patients with severe acute pancreatitis. Early prophylactic antibiotic treatment is effective in preventing conversion of sterile necrosis to pancreatic infection, but its effect on mortality remains unproven. Fungal infections may predict a worse outcome, but no evidence supports the use of antifungal prophylaxis. Because infection of pancreatic necrosis by enteric bacteria can develop despite prophylaxis, a high index of suspicion should allow early detection followed by aggressive management.