Clinicopathological and prognostic significance of circulating tumor cells in patients with gastric cancer: A meta-analysis
Clinicopathological and prognostic significance of circulating tumor cells in patients with gastric cancer: A meta-analysis
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胃癌患者循环肿瘤细胞的临床病理学和预后意义：荟萃分析
DOI：
10.1002/ijc.28954
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发表时间：
2015-01-01
影响因子：
6.4
通讯作者：
Wang, Zhenning
中科院分区：
文献类型：
--
作者：
Huang, Xuanzhang;Gao, Peng;Wang, Zhenning
循环肿瘤细胞（CTC）和播散肿瘤细胞（DTC）在胃癌（GC）患者中的预后意义存在争议。我们的荟萃分析的目的是评估其与胃癌临床病理特征和预后意义的相关性。系统检索PubMed、Embase、科克伦数据库、Science引文索引、CNKI数据库和相关研究的参考文献（截至2013年11月）。采用随机效应模型，以比值比（OR）、危险比（HR）和95%可信区间（CI）作为效应值进行Meta分析。分析了26项研究，包括2，566例GC患者.总体分析显示，肿瘤细胞的发生率差异当比较I/II期组与III/IV期组时，（OR = 0.36，CI [0.23，0.56]），Lauren弥漫组优于肠内组（OR = 2.06，CI [1.06，4.00]），低分化组与高/中分化组（OR = 1.65，CI [1.10，2.50]），淋巴结转移阳性组与淋巴结转移阳性组比较（OR = 2.92，CI [1.00，8.55]）。CTC/DTC的检出与患者的无病生存期显著相关（HR = 3.42，CI [2.39，4.91]），外周血CTC的检出与患者的总生存期显著相关（HR = 2.13，CI [1.13，4.03]）。我们的荟萃分析表明，CTC/DTC的检测与GC患者的预后相关，因此可以作为GC分期的基础。
The prognostic significance of circulating tumor cells (CTCs) and disseminated tumor cells (DTCs) in patients with gastric cancer (GC) is controversial. The aims of our meta- analysis are to assess its correlation with clinicopathological characteristics and prognostic significance in GC. PubMed, Embase, the Cochrane database, the Science citation index, the CNKI database and the references of relevant studies were systematically searched (up to November, 2013). Using the random- effect model, the meta- analysis was completed with odds ratio (OR), risk ratio, hazard ratio (HR) and 95% confidence intervals (CI) as effect values. Twenty- six studies containing 2,566 patients with GC were analyzed. The overall analysis showed that the incidence difference of tumor cells (CTCs/DTCs) was significant when comparing the stage I/II group to the stage III/IV group (OR = 0.36, CI [0.23, 0.56]), the Lauren diffuse group to the intestinal group (OR = 2.06, CI [1.06, 4.00]), the poorly differentiated group to the well/moderate group (OR = 1.65, CI [1.10, 2.50]), the lymphatic involvement positive group to the positive group (OR = 2.92, CI [1.00, 8.55]). The detection of CTCs/DTCs was significantly related with the disease- free survival of patients (HR = 3.42, CI [2.39, 4.91]) and the detection of CTCs in peripheral blood was significantly related with the overall survival of patients (HR = 2.13, CI [1.13, 4.03]). Our meta- analysis indicates that detection of CTCs/DTCs is associated with prognosis for patients with GC and thus could act as a basis for GC staging.