Neurotoxicity of MAO metabolites of catecholamine neurotransmitters: Role in neurodegenerative diseases
Neurotoxicity of MAO metabolites of catecholamine neurotransmitters: Role in neurodegenerative diseases
复制标题
DOI：
10.1016/s0161-813x(03)00090-1
复制
发表时间：
2004-01-01
期刊：
影响因子：
3.4
通讯作者：
Zahm, DS
中科院分区：
文献类型：
--
作者：
Burke, WJ;Li, SW;Zahm, DS
去甲肾上腺素（NE）或肾上腺素（EPI）和多巴胺（DA）的单胺氧化酶（MAO）代谢物分别为3，4-二羟基苯乙醇酸（DOPEGAL）和3，4-二羟基苯乙醛（DOPAL）。这些儿茶酚胺（CA）MAO代谢产物的毒性在50多年前就被预测。然而，直到我们最近的化学合成这些CA醛代谢物，关于它们的毒性的假设不能被测试。本文综述了近年来对这类化合物的研究进展。审查的主题包括：DOPEGAL和DOPAL的化学合成和性质; CA醛的体外和体内毒性;毒性的亚细胞机制; DOPEGAL与DOPAL的自由基形成; CA醛在阿尔茨海默病（AD）和帕金森病（PD）中的积累机制以及阿尔茨海默病和帕金森病的潜在治疗靶点。(C)2003年由Elsevier Inc.出版
The monoamine oxidase (MAO) metabolites of norepinephrine (NE) or epinephrine (EPI) and of dopamine (DA) are 3,4-dihydroxyphenyglycolaldehye (DOPEGAL) and 3,4-dihydroxyphenylacetaldehyde (DOPAL), respectively. The toxicity of these catecholamine (CA) MAO metabolites was predicted over 50 years ago. However, until our recent chemical synthesis of these CA aldehyde metabolites, the hypothesis about their toxicity could not be tested. The present paper reviews recent knowledge gained about these compounds. Topics to be reviewed include: chemical synthesis and properties of DOPEGAL and DOPAL; in vitro and in vivo toxicity of CA aldehydes; subcellular mechanisms of toxicity; free radical formation by DOPEGAL versus DOPAL; mechanisms of accumulation of CA aldehydes in Alzheimer's disease (AD) and Parkinson's disease (PD) and potential therapeutic targets in Alzheimer's disease and Parkinson's disease. (C) 2003 Published by Elsevier Inc.