Differences in recruitment and early retention among ethnic minority participants in a large pediatric cohort: the TEDDY Study.
Differences in recruitment and early retention among ethnic minority participants in a large pediatric cohort: the TEDDY Study.
复制标题
DOI：
10.1016/j.cct.2012.03.009
复制
发表时间：
2012-07
影响因子：
2.2
通讯作者：
TEDDY Study Group
中科院分区：
文献类型：
--
作者：
Baxter J;Vehik K;Johnson SB;Lernmark B;Roth R;Simell T;TEDDY Study Group
TEDDY 研究是一项国际多中心前瞻性研究，旨在确定遗传风险儿童 1 型糖尿病 (T1D) 的环境诱因。本报告调查了美国中心的少数族裔 (EM) 入学和保留模式的差异。截至2009年6月，已有267,739名新生儿在出生时接受了高风险T1D基因型筛查。使用在筛选、登记和基线访视时收集的数据。描述性和多元逻辑回归分析评估了 EM 组之间在排除、入组和提前退出方面的差异。在 10,975 名符合条件的受试者中，有 6,912 名（67%）受邀参加。 EM 受试者更有可能因无法联系而被排除在外。在受邀者中，有 3,265 名 (47%) 在 4.5 个月大时注册。调整后的分析显示，除了那些被归类为其他少数族裔的人外，各组的入学几率相似。 EM 受试者的早期退出率较高。调整后的模型表明，这种情况在西班牙裔受试者中的可能性明显更大。了解与少数族裔参与研究相关的模式可以扩展我们做出更准确推论的能力，并允许评估促进纳入少数族裔的策略，以更好地解决健康差距。
The TEDDY Study is an international, multi-center prospective study designed to identify the environmental triggers of type 1 diabetes (T1D) in genetically at-risk children. This report investigates ethnic minority (EM) differences in patterns of enrollment and retention in the US centers. As of June 2009, 267,739 newborns had been screened at birth for high risk T1D genotypes. Data collected at the time of screening, enrollment and at the baseline visit were used. Descriptive and multiple-logistic regression analyses assessed differences between EM groups regarding exclusion, enrollment and early withdrawal. Of the 10,975 eligible subjects, 6,912 (67%) were invited to participate. EM subjects were more likely to be excluded because of an inability to contact. Of those invited 3,265 (47%) enrolled by the age of 4.5 months. Adjusted analyses showed that except for those classified as other EM, the odds of enrolling were similar across groups. EM subjects had elevated early withdrawal rates. Adjusted models demonstrated that this was significantly more likely among Hispanic subjects. Understanding patterns associated with EM participation in research extends our ability to make more accurate inferences and permits assessment of strategies that promote inclusion of EM to better address health disparities.
登录
查看更多内容
影响因子：
2.2
作者：
Lernmark B;Johnson SB;Vehik K;Smith L;Ballard L;Baxter J;McLeod W;Roth R;Simell T
通讯作者：
Simell T
影响因子：
3.6
作者：
Zebracki, K;Drotar, D;Walders, N
通讯作者：
Walders, N
影响因子：
3.9
作者：
Loftin, WA;Barnett, SK;Sullivan, P
通讯作者：
Sullivan, P
DOI：
10.1111/j.1467-842x.2006.tb00849.x
发表时间：
2006-08-01
影响因子：
3.5
作者：
Young, Anne F.;Powers, Jennifer R.;Bell, Sandra L.
通讯作者：
Bell, Sandra L.
DOI：
10.1196/annals.1447.062
发表时间：
2008-01-01
期刊：
IMMUNOLOGY OF DIABETES V: FROM BENCH TO BEDSIDE
影响因子：
--
作者：
Rewers, Marian
通讯作者：
Rewers, Marian