Genetic variations in humans associated with differences in the course of hepatitis C
Genetic variations in humans associated with differences in the course of hepatitis C
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DOI：
10.1016/j.bbrc.2004.03.056
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发表时间：
2004-04-30
影响因子：
3.1
通讯作者：
Kawata, S
中科院分区：
文献类型：
--
作者：
Saito, T;Ji, G;Kawata, S
丙型肝炎病毒（HCV）感染的结果因人而异，但所涉及的遗传因素仍不清楚。我们进行了一项以人群为基础的关联研究，其中238名日本人抗HCV抗体阳性的269个单核苷酸多态性（SNP）的基因分型在103个候选基因，可能会影响感染的过程。共列出32个基因的50个SNP。IL4、IL8RB、IL10RA、PRL、ADA、NFKB 1、GRAP2、CABIN1、IFNAR2、IFI27、IFI41、TNFRSF1A、ALDOB、AP1B1、SULT2B1、EGF、EGFR、TGFB1、LTBP 2和CD 4的遗传多态性与持续性病毒血症相关IL1B、IL1RL1、IL2RB、IL12RB1、IL18R1、STAT5A、GRAP2、CABIN1、IFNAR1、Mx1、BMP 8、FGL 1、LTBP 2、CD34、和CD 80与HCV携带者不同血清丙氨酸氨基转移酶水平相关（P < 0.05）。分类的基因使我们能够为未来的HCV感染研究提出新的假设，以最终确定真正的基因及其变异。(C)2004年爱思唯尔公司All rights reserved.
The outcome of hepatitis C virus (HCV) infection varies among individuals, but the genetic factors involved remain unknown. We conducted a population-based association study in which 238 Japanese individuals positive for anti-HCV antibody were genotyped for 269 single nucleotide polymorphisms (SNPs) in 103 candidate genes that might influence the course of infection. Altogether, 50 SNPs in 32 genes were listed. Genetic polymorphisms in IL4, IL8RB, 1L10RA, PRL, ADA, NFKB1, GRAP2, CABIN1, IFNAR2, IFI27, IFI41, TNFRSF1A, ALDOB, AP1B1, SULT2B1, EGF, EGFR, TGFB1, LTBP2, and CD4 were associated with persistent viremia (P < 0.05), whereas those in IL1B, IL1RL1, IL2RB, IL12RB1, IL18R1, STAT5A, GRAP2, CABIN1, IFNAR1, Mx1, BMP8, FGL1, LTBP2, CD34, and CD80 were associated with different serum alanine aminotransferase levels in HCV carriers (P < 0.05). The sorted genes allow us to draw novel hypotheses for future studies of HCV infection to ultimately identify bona fide genes and their variations. (C) 2004 Elsevier Inc. All rights reserved.