The study of untreated syphilis in the Negro male
The study of untreated syphilis in the Negro male
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DOI：
10.1016/s0360-3016(97)00835-3
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发表时间：
1998-01-01
影响因子：
7
通讯作者：
Brawley, OW
中科院分区：
文献类型：
--
作者：
Brawley, OW
目的：少数群体参与临床研究是很多讨论的主题，甚至已成为联邦法律的主题。这个项目被称为塔斯基吉梅毒研究，正式名称为“塔斯基吉对黑人男性未经治疗的梅毒研究”，是美国医学的重大失败之一，也是国家耻辱，尽管它的存在是众所周知的，但许多人不知道该研究的历史事实，也不知道该研究的背景，我在这里的目的是重述该研究的事实及其历史背景。美国参议院对该研究的调查、国家医学图书馆中的原始论文以及有关该试验的书籍。 结果：该试验于 1931 年开始，旨在调查黑人男性中未经治疗的三期梅毒的自然史。这项研究招募了 399 名梅毒男性和 201 名未感染梅毒的男性作为对照，所有入组时年龄均至少 25 岁。这些人被告知他们正在参加一项研究，但从未接受过有关其影响的教育。后来，人们没有被告知有一种有效的治疗方法可以治疗他们的疾病，这种治疗方法被拒绝提供给他们，这项试验一直持续到 1972 年。结论：导致这项研究并使其持续 40 年的许多问题仍然存在，对未经治疗的黑人进行的未经治疗的梅毒公共卫生研究的教训包括家长作风、傲慢、盲目忠诚和滥用科学的危险，“那些不欣赏历史的人注定要重复一遍”（阿尔弗雷德·诺斯·怀特海）。 (C) 1998 爱思唯尔科学公司。
Purpose: The participation of minorities in clinical studies is the subject of much discussion and has even become the subject of Federal law. The project known as the Tuskegee Syphilis Study and officially titled "The Tuskegee Study of Untreated Syphilis in the Negro Male," is one of the great debacles of American medicine and a national shame, Despite the fact that its existence is,yell known, many do not know the historical facts of the study nor the context of the study, My purpose here is to recount the facts of the study and its historical context,Methods: The history recounted here Is taken from documents gathered during a U.S. Senate investigation of the study, original papers located in National Library of Medicine, and books about the trial.Results: The trial began in 1931 as a survey of the natural history of untreated tertiary syphilis in Black men. This study enrolled 399 men with syphilis and 201 uninfected men to serve as controls, All were at least 25 years old at enrollment. The men were told they were in a study, but never educated about the implications. Later, men were not informed that there was a treatment for effective treatment for their disease-a treatment that was being withheld from them, This trial continued till 1972.Conclusion: Many of the issues that led to the study and caused it to continue for 40 years still exist, The lessons of the Public Health Study of Untreated Syphilis in the Untreated Negro include the dangers of paternalism, arrogance, blind loyalty, and misuse of science, "Those who do not appreciate history are condemned to repeat it" (Alfred North Whitehead). (C) 1998 Elsevier Science Inc.