Efficacy of Single-Dose Primaquine With Artemisinin Combination Therapy on Plasmodium falciparum Gametocytes and Transmission: An Individual Patient Meta-Analysis.
Efficacy of Single-Dose Primaquine With Artemisinin Combination Therapy on Plasmodium falciparum Gametocytes and Transmission: An Individual Patient Meta-Analysis.
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DOI：
10.1093/infdis/jiaa498
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发表时间：
2022-04-01
期刊：
影响因子：
--
通讯作者：
Bousema T
中科院分区：
文献类型：
--
作者：
Stepniewska K;Humphreys GS;Gonçalves BP;Craig E;Gosling R;Guerin PJ;Price RN;Barnes KI;Raman J;Smit MR;D'Alessandro U;Stone WJR;Bjorkman A;Samuels AM;Arroyo-Arroyo MI;Bastiaens GJH;Brown JM;Dicko A;El-Sayed BB;Elzaki SG;Eziefula AC;Kariuki S;Kwambai TK;Maestre AE;Martensson A;Mosha D;Mwaiswelo RO;Ngasala BE;Okebe J;Roh ME;Sawa P;Tiono AB;Chen I;Drakeley CJ;Bousema T
Since the World Health Organization recommended single low-dose (0.25 mg/kg) primaquine (PQ) in combination with artemisinin-based combination therapies (ACTs) in areas of low transmission or artemisinin-resistant Plasmodium falciparum, several single-site studies have been conducted to assess efficacy. An individual patient meta-analysis to assess gametocytocidal and transmission-blocking efficacy of PQ in combination with different ACTs was conducted. Random effects logistic regression was used to quantify PQ effect on (1) gametocyte carriage in the first 2 weeks post treatment; and (2) the probability of infecting at least 1 mosquito or of a mosquito becoming infected. In 2574 participants from 14 studies, PQ reduced PCR-determined gametocyte carriage on days 7 and 14, most apparently in patients presenting with gametocytemia on day 0 (odds ratio [OR], 0.22; 95% confidence interval [CI], .17–.28 and OR, 0.12; 95% CI, .08–.16, respectively). Rate of decline in gametocyte carriage was faster when PQ was combined with artemether-lumefantrine (AL) compared to dihydroartemisinin-piperaquine (DP) (P = .010 for day 7). Addition of 0.25 mg/kg PQ was associated with near complete prevention of transmission to mosquitoes. Transmission blocking is achieved with 0.25 mg/kg PQ. Gametocyte persistence and infectivity are lower when PQ is combined with AL compared to DP. An individual patient meta-analysis was performed on the gametocytocidal and transmission-blocking activities of single-dose primaquine. Gametocyte persistence and infectivity depended on the artemisinin-combination therapy that primaquine was administered with. Primaquine’s transmission-blocking effects were achieved at 0.25 mg/kg.
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影响因子：
--
作者：
Landier J;Kajeechiwa L;Thwin MM;Parker DM;Chaumeau V;Wiladphaingern J;Imwong M;Miotto O;Patumrat K;Duanguppama J;Cerqueira D;Malleret B;Rénia L;Nosten S;von Seidlein L;Ling C;Proux S;Corbel V;Simpson JA;Dondorp AM;White NJ;Nosten FH
通讯作者：
Nosten FH
影响因子：
17.1
作者：
Joice R;Nilsson SK;Montgomery J;Dankwa S;Egan E;Morahan B;Seydel KB;Bertuccini L;Alano P;Williamson KC;Duraisingh MT;Taylor TE;Milner DA;Marti M
通讯作者：
Marti M
影响因子：
4.3
作者：
Johnston GL;Gething PW;Hay SI;Smith DL;Fidock DA
通讯作者：
Fidock DA
影响因子：
3
作者：
Konate, Drissa;Diawara, Sory, I;Diakite, Mahamadou
通讯作者：
Diakite, Mahamadou
影响因子：
56.3
作者：
Dicko, Alassane;Brown, Joelle M.;Gosling, Roly
通讯作者：
Gosling, Roly